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Cdc25b cell division cycle 25B [ Rattus norvegicus (Norway rat) ]

Gene ID: 171103, updated on 27-Nov-2024

Summary

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Official Symbol
Cdc25bprovided by RGD
Official Full Name
cell division cycle 25Bprovided by RGD
Primary source
RGD:621500
See related
EnsemblRapid:ENSRNOG00000021248 AllianceGenome:RGD:621500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of cell cycle process; and protein phosphorylation. Predicted to act upstream of or within female meiosis I; oocyte maturation; and positive regulation of protein kinase activity. Predicted to be located in centrosome and spindle pole. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDC25B (cell division cycle 25B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 404.3), Lung (RPKM 87.2) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdc25b in Genome Data Viewer
Location:
3q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138860148..138870287)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118407127..118417272)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123731539..123741696)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene centromere protein B Neighboring gene uncharacterized LOC134486156 Neighboring gene adaptor related protein complex 5 subunit sigma 1 Neighboring gene mitochondrial antiviral signaling protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Development of a multiplex quantitative PCR signature to predict progression in non-muscle-invasive bladder cancer. Wang R, et al. Cancer Res, 2009 May 1. PMID 19383904, Free PMC Article
  2. Expression of cdc25A and cdc25B phosphatase in breast carcinoma. Ito Y, et al. Breast Cancer, 2004. PMID 15550849
  3. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Lincoln AJ, et al. Nat Genet, 2002 Apr. PMID 11912493
  4. Cdc25A is a novel phosphatase functioning early in the cell cycle. Jinno S, et al. EMBO J, 1994 Apr 1. PMID 8156993, Free PMC Article
  5. The role of 14-3-3ε interaction with phosphorylated Cdc25B at its Ser321 in the release of the mouse oocyte from prophase I arrest. Meng J, et al. PLoS One, 2013. PMID 23326474, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in female meiosis I IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within female meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in oocyte maturation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oocyte maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell cycle G2/M phase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
M-phase inducer phosphatase 2
Names
dual specificity phosphatase Cdc25B
NP_001376142.1
NP_598256.2
XP_038960121.1
XP_038960123.1
XP_063139110.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389213.1 → NP_001376142.1  M-phase inducer phosphatase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6A7K8, A0A8I6GIX5
    Related
    ENSRNOP00000091343.2, ENSRNOT00000119042.2
    Conserved Domains (2) summary
    cd01530
    Location:381 → 500
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:111 → 352
    M-inducer_phosp; M-phase inducer phosphatase

  2. NM_001429734.1 → NP_001416663.1  M-phase inducer phosphatase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001429735.1 → NP_001416664.1  M-phase inducer phosphatase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_133572.2 → NP_598256.2  M-phase inducer phosphatase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P48966
    UniProtKB/TrEMBL
    A6HQC8, F1LQS5
    Related
    ENSRNOP00000106275.1, ENSRNOT00000122290.1
    Conserved Domains (2) summary
    cd01530
    Location:407 → 526
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:111 → 378
    M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    138860148..138870287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283040.1 → XP_063139110.1  M-phase inducer phosphatase 2 isoform X2

    Related
    ENSRNOP00000088213.2, ENSRNOT00000101513.2

  2. XM_039104193.2 → XP_038960121.1  M-phase inducer phosphatase 2 isoform X1

    Related
    ENSRNOP00000096779.1, ENSRNOT00000103719.2
    Conserved Domains (2) summary
    cd01530
    Location:393 → 512
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:111 → 364
    M-inducer_phosp; M-phase inducer phosphatase

  3. XM_039104195.2 → XP_038960123.1  M-phase inducer phosphatase 2 isoform X3

    Conserved Domains (2) summary
    cd01530
    Location:209 → 328
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:1 → 180
    M-inducer_phosp; M-phase inducer phosphatase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48966.1 GenPept UniProtKB/Swiss-Prot:P48966

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