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Timm9 translocase of inner mitochondrial membrane 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171139, updated on 27-Nov-2024

Summary

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Official Symbol
Timm9provided by RGD
Official Full Name
translocase of inner mitochondrial membrane 9provided by RGD
Primary source
RGD:621656
See related
EnsemblRapid:ENSRNOG00000008222 AllianceGenome:RGD:621656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tim9; Tim9a; Timm9a
Summary
Predicted to enable membrane insertase activity; protein homodimerization activity; and protein-folding chaperone binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex and mitochondrial intermembrane space protein transporter complex. Orthologous to human TIMM9 (translocase of inner mitochondrial membrane 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 169.5), Kidney (RPKM 162.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Timm9 in Genome Data Viewer
Location:
6q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (95346065..95358895, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (89610094..89622924, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (93549484..93562314, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 3 Neighboring gene AT-rich interaction domain 4A Neighboring gene translocase of outer mitochondrial membrane 20 like Neighboring gene KIAA0586 homolog Neighboring gene dishevelled-binding antagonist of beta-catenin 1 Neighboring gene similar to ATPase inhibitory factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The role of the TIM8-13 complex in the import of Tim23 into mitochondria. Paschen SA, et al. EMBO J, 2000 Dec 1. PMID 11101512, Free PMC Article
  2. Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. Webb CT, et al. Mol Cell, 2006 Jan 6. PMID 16387659
  3. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. Mühlenbein N, et al. J Biol Chem, 2004 Apr 2. PMID 14726512
  4. Assembly of β-barrel proteins in the mitochondrial outer membrane. Höhr AI, et al. Biochim Biophys Acta, 2015 Jan. PMID 25305573
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables membrane insertase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein insertion into mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial intermembrane space protein transporter complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit Tim9
Names
translocase of inner mitochondrial membrane 9 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276429.1 → NP_001263358.1  mitochondrial import inner membrane translocase subunit Tim9

    See identical proteins and their annotated locations for NP_001263358.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    FM052814, JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q9WV97
    UniProtKB/TrEMBL
    A6HC17
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  2. NM_001276430.1 → NP_001263359.1  mitochondrial import inner membrane translocase subunit Tim9

    See identical proteins and their annotated locations for NP_001263359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    FM056491, JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q9WV97
    UniProtKB/TrEMBL
    A6HC17
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  3. NM_133604.1 → NP_598288.1  mitochondrial import inner membrane translocase subunit Tim9

    See identical proteins and their annotated locations for NP_598288.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    CB775939, JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q9WV97
    UniProtKB/TrEMBL
    A6HC17
    Related
    ENSRNOP00000010871.3, ENSRNOT00000010871.7
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RNA

  1. NR_075101.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    DV726219, JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    95346065..95358895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261517.1 → XP_063117587.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

    UniProtKB/Swiss-Prot
    Q9WV97
    UniProtKB/TrEMBL
    A6HC17

  2. XM_039111743.1 → XP_038967671.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

    UniProtKB/Swiss-Prot
    Q9WV97
    UniProtKB/TrEMBL
    A6HC17
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  3. XM_063261516.1 → XP_063117586.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

    UniProtKB/Swiss-Prot
    Q9WV97
    UniProtKB/TrEMBL
    A6HC17
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV97.3 GenPept UniProtKB/Swiss-Prot:Q9WV97

Gene LinkOut

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