RHOV ras homolog family member V [Homo sapiens (human)] - Gene

Summary

Official Symbol: RHOVprovided by HGNC
Official Full Name: ras homolog family member Vprovided by HGNC
Primary source: HGNC:HGNC:18313
See related: Ensembl:ENSG00000104140 MIM:620101; AllianceGenome:HGNC:18313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CHP; ARHV; WRCH2
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Predicted to be located in endosome membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in esophagus (RPKM 34.6), skin (RPKM 27.2) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q15.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (40872214..40874234, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (38678234..38680254, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (41164412..41166432, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of RHOV signaling by interaction with SH3 domain-containing adaptor proteins and phosphorylation by PKA.
Title: Regulation of RHOV signaling by interaction with SH3 domain-containing adaptor proteins and phosphorylation by PKA.
Prognostic significance of the rho GTPase RHOV and its role in tumor immune cell infiltration: a comprehensive pan-cancer analysis.
Title: Prognostic significance of the rho GTPase RHOV and its role in tumor immune cell infiltration: a comprehensive pan-cancer analysis.
In vivo CRISPR screens identify RhoV as a pro-metastasis factor of triple-negative breast cancer.
Title: In vivo CRISPR screens identify RhoV as a pro-metastasis factor of triple-negative breast cancer.
RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway.
Title: RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway.
A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry.
Title: A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry.
Our results suggest that the effector domain of RhoV mediates its binding to Pak1, complementing the current view of the molecular basics of RhoV binding to effectors of the Pak family.
Title: [Mutations in the Effector Domain of RhoV GTPase Impair Its Binding to Pak1 Protein Kinase].
This review addresses the developmental roles of 2 GTPases of the Rho family, RhoV/Chp and RhoU/Wrch.
Title: Atypical RhoV and RhoU GTPases control development of the neural crest.
Authors propose that the RHOV gene could be validated as a diagnostic or prognostic marker for NSCLC, and that observed overexpression of RHOV might contribute to tumorigenesis.
Title: The RHOV gene is overexpressed in human non-small cell lung cancer.
CDC42 homologous protein does not enhance the level of Ser60 phosphorylation in Pak6. (RHO V protein)
Title: Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV.
Results demonstrate a novel mechanism of signal termination mediated by the Rho-family GTPases Chp and Cdc42, which results in ubiquitin-mediated degradation of one of their direct effectors, Pak1.
Title: Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: rho-related GTP-binding protein RhoV

Names: CDC42-like GTPase 2; GTP-binding protein-like 2; Rho GTPase-like protein ARHV; WRCH-2; WRCH1-related GTPase; Wnt-1 regulated Cdc42 homolog 2; Wnt-1 responsive Cdc42 homolog 2; ras homolog gene family, member V

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133639.4 → NP_598378.3 rho-related GTP-binding protein RhoV

See identical proteins and their annotated locations for NP_598378.3

Status: VALIDATED

Source sequence(s)

AC025166, BC112945

Consensus CDS

CCDS10068.1

UniProtKB/Swiss-Prot

Q2KHQ5, Q8TDW6, Q96L33

UniProtKB/TrEMBL

Q05D03

Related

ENSP00000220507.4, ENST00000220507.5

Conserved Domains (1) summary

cd04130
Location:32 → 205

Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42