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Timd2 T cell immunoglobulin and mucin domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 171284, updated on 27-Nov-2024

Summary

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Official Symbol
Timd2provided by MGI
Official Full Name
T cell immunoglobulin and mucin domain containing 2provided by MGI
Primary source
MGI:MGI:2159681
See related
Ensembl:ENSMUSG00000040413 AllianceGenome:MGI:2159681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G9D3; Tim2; TIM-2
Summary
Enables ferritin receptor activity. Acts upstream of or within iron ion transport. Located in cell surface. Is expressed in 4-cell stage embryo; liver; liver left lobe; liver right lobe; and metanephros. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in placenta adult (RPKM 18.2), liver adult (RPKM 17.7) and 4 other tissues See more
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Genomic context

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See Timd2 in Genome Data Viewer
Location:
11 B1.1; 11 28.05 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (46559787..46597934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46668960..46707107, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 1 Neighboring gene T cell immunoglobulin and mucin domain containing 7, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3944 Neighboring gene STARR-seq mESC enhancer starr_29333 Neighboring gene predicted gene 12174 Neighboring gene hepatitis A virus cellular receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TIM2 modulates retinal iron levels and is involved in blood-retinal barrier breakdown. Valença A, et al. Exp Eye Res, 2021 Jan. PMID 33065090
  2. T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase. Fukushima A, et al. Immunol Lett, 2007 Jun 15. PMID 17532058
  3. Cutting edge: inhibition of T cell activation by TIM-2. Knickelbein JE, et al. J Immunol, 2006 Oct 15. PMID 17015678
  4. TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity. Krishnamoorthy A, et al. Toxicol Sci, 2010 Nov. PMID 20702592, Free PMC Article
  5. T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. Rennert PD, et al. J Immunol, 2006 Oct 1. PMID 16982865

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We concluded that pro-apoptotic effects on Th1 population through galectin-9-Tim-3 pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica.
    Title: Tim-2 up-regulation and galectin-9-Tim-3 pathway activation in Th2-biased response in Schistosoma japonicum infection in mice.
  2. TIM-2 signaling influences both proliferation and antibody production of B cells during the early phase of collagen-induced arthritis
    Title: Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells.
  3. TIM-2 can function as an iron uptake pathway.
    Title: Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells.
  4. The increased expression of the pro-inflammatory and proapoptotic genes, a higher number of apoptotic cells, and increased injury and mortality of the TIM2-deficient mice suggest a protective role of TIM2 in cisplatin-induced nephrotoxicity.
    Title: TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity.
  5. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.
    Title: TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.
  6. There are Tim2-binding molecules on hepatocytes. Tim2-hFc inhibited differentiation & proliferation of hepatocytes in fetal liver primary culture. Down-regulation of Tim2 expression by siRNA enhanced expression of liver differentiation marker genes.
    Title: Tim2 is expressed in mouse fetal hepatocytes and regulates their differentiation.
  7. The mTIM-1 structure identified a homophilic TIM-TIM adhesion interaction, whereas the mTIM-2 domain formed a dimer that prevented homophilic binding.
    Title: Structures of T Cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family.
  8. expression of TIM-2 significantly impairs the induction of NFAT and AP-1 transcriptional reporters
    Title: Cutting edge: inhibition of T cell activation by TIM-2.
  9. Tim-2 negatively regulates the Th2 differentiation of Ag-primed T-cells and the development of EC during the effector phase.
    Title: T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ferritin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables virus receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within iron ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mast cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-cell immunoglobulin and mucin domain-containing protein 2
Names
T-cell immunoglobulin mucin receptor 2
T-cell membrane protein 2
TIMD-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161355.1 → NP_001154827.1  T-cell immunoglobulin and mucin domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_001154827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), variant 2 and variant 3 encode the same protein.
    Source sequence(s)
    AK145630, AK163225, AK166877, CB953226
    Consensus CDS
    CCDS24582.1
    UniProtKB/Swiss-Prot
    Q8R183, Q8VBW0
    UniProtKB/TrEMBL
    A8C1R4
    Related
    ENSMUSP00000104848.3, ENSMUST00000109225.9
    Conserved Domains (1) summary
    pfam07686
    Location:30 → 119
    V-set; Immunoglobulin V-set domain

  2. NM_001161356.1 → NP_001154828.1  T-cell immunoglobulin and mucin domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_001154828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AB009015, AK145630, AK166877
    Consensus CDS
    CCDS24582.1
    UniProtKB/Swiss-Prot
    Q8R183, Q8VBW0
    UniProtKB/TrEMBL
    A8C1R4
    Related
    ENSMUSP00000131540.2, ENSMUST00000169584.8
    Conserved Domains (1) summary
    pfam07686
    Location:30 → 119
    V-set; Immunoglobulin V-set domain

  3. NM_134249.5 → NP_599010.4  T-cell immunoglobulin and mucin domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_599010.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK145630, AK163225, AK166877, BY731803
    Consensus CDS
    CCDS24582.1
    UniProtKB/Swiss-Prot
    Q8R183, Q8VBW0
    UniProtKB/TrEMBL
    A8C1R4
    Related
    ENSMUSP00000060891.7, ENSMUST00000055102.13
    Conserved Domains (1) summary
    pfam07686
    Location:30 → 119
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    46559787..46597934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245625.1 → XP_030101485.1  T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8R183, Q8VBW0
    UniProtKB/TrEMBL
    A8C1R4
    Conserved Domains (1) summary
    pfam07686
    Location:30 → 119
    V-set; Immunoglobulin V-set domain

  2. XM_030245624.1 → XP_030101484.1  T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8R183, Q8VBW0
    UniProtKB/TrEMBL
    A8C1R4
    Conserved Domains (1) summary
    pfam07686
    Location:30 → 119
    V-set; Immunoglobulin V-set domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R183.1 GenPept UniProtKB/Swiss-Prot:Q8R183

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