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Slc12a8 solute carrier family 12 (potassium/chloride transporters), member 8 [ Mus musculus (house mouse) ]

Gene ID: 171286, updated on 27-Nov-2024

Summary

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Official Symbol
Slc12a8provided by MGI
Official Full Name
solute carrier family 12 (potassium/chloride transporters), member 8provided by MGI
Primary source
MGI:MGI:2443672
See related
Ensembl:ENSMUSG00000035506 AllianceGenome:MGI:2443672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCC9; E330020C02Rik
Summary
Predicted to enable potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Is expressed in lateral hypothalamic area and metanephros. Orthologous to human SLC12A8 (solute carrier family 12 member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 32.3), large intestine adult (RPKM 19.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Slc12a8 in Genome Data Viewer
Location:
16 B3; 16 24.12 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33337440..33484508)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33517328..33664138)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700007L15 gene Neighboring gene STARR-seq mESC enhancer starr_40693 Neighboring gene zinc finger protein 148 Neighboring gene STARR-seq mESC enhancer starr_40697 Neighboring gene STARR-seq mESC enhancer starr_40698 Neighboring gene STARR-seq mESC enhancer starr_40700 Neighboring gene STARR-seq mESC enhancer starr_40702 Neighboring gene STARR-positive B cell enhancer ABC_E5537 Neighboring gene STARR-seq mESC enhancer starr_40703 Neighboring gene heart development protein with EGF-like domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E11611 Neighboring gene STARR-seq mESC enhancer starr_40709 Neighboring gene predicted gene 15658 Neighboring gene mucin 13, epithelial transmembrane

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Slc12a8 is a nicotinamide mononucleotide transporter. Grozio A, et al. Nat Metab, 2019 Jan. PMID 31131364, Free PMC Article
  2. Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging. Ito N, et al. Cell Rep, 2022 Jul 26. PMID 35905718
  3. Cation-chloride cotransporters and neuronal function. Blaesse P, et al. Neuron, 2009 Mar 26. PMID 19323993
  4. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride:monoatomic cation symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in inorganic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 12 member 8
Names
cation-chloride cotransporter 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083902.2 → NP_001077371.1  solute carrier family 12 member 8 isoform 2

    See identical proteins and their annotated locations for NP_001077371.1

    Status: VALIDATED

    Source sequence(s)
    AC121570, AC127412
    Consensus CDS
    CCDS37317.1
    UniProtKB/TrEMBL
    D3Z6X1
    Related
    ENSMUSP00000113633.2, ENSMUST00000119173.8
    Conserved Domains (1) summary
    TIGR00930
    Location:3 → 340
    2a30; K-Cl cotransporter

  2. NM_001370999.1 → NP_001357928.1  solute carrier family 12 member 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121570, AC127412, AF319951, AK165080, BU921470
    Consensus CDS
    CCDS49834.1
    UniProtKB/Swiss-Prot
    Q3TNQ9, Q8K0M9, Q8VI23
    UniProtKB/TrEMBL
    D3Z6X1
    Related
    ENSMUSP00000112439.2, ENSMUST00000121925.8
    Conserved Domains (1) summary
    TIGR00930
    Location:34 → 420
    2a30; K-Cl cotransporter

  3. NM_134251.3 → NP_599012.2  solute carrier family 12 member 8 isoform 1

    See identical proteins and their annotated locations for NP_599012.2

    Status: VALIDATED

    Source sequence(s)
    AC121570, AC127412, AF319951, AK165080, BU921470
    Consensus CDS
    CCDS49834.1
    UniProtKB/Swiss-Prot
    Q3TNQ9, Q8K0M9, Q8VI23
    UniProtKB/TrEMBL
    D3Z6X1
    Related
    ENSMUSP00000062337.9, ENSMUST00000059056.15
    Conserved Domains (1) summary
    TIGR00930
    Location:34 → 420
    2a30; K-Cl cotransporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    33337440..33484508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521823.5 → XP_006521886.1  solute carrier family 12 member 8 isoform X2

    UniProtKB/TrEMBL
    D3Z6X1
    Conserved Domains (1) summary
    TIGR00930
    Location:34 → 420
    2a30; K-Cl cotransporter

  2. XM_036159807.1 → XP_036015700.1  solute carrier family 12 member 8 isoform X6

    UniProtKB/TrEMBL
    D3Z6X1
    Related
    ENSMUSP00000113164.2, ENSMUST00000122427.8
    Conserved Domains (1) summary
    TIGR00930
    Location:34 → 420
    2a30; K-Cl cotransporter

  3. XM_030248992.2 → XP_030104852.1  solute carrier family 12 member 8 isoform X3

    Conserved Domains (1) summary
    TIGR00930
    Location:34 → 382
    2a30; K-Cl cotransporter

  4. XM_006521825.4 → XP_006521888.1  solute carrier family 12 member 8 isoform X4

    UniProtKB/TrEMBL
    D3Z6X1
    Conserved Domains (1) summary
    TIGR00930
    Location:34 → 371
    2a30; K-Cl cotransporter

  5. XM_030248993.2 → XP_030104853.1  solute carrier family 12 member 8 isoform X5

    Conserved Domains (1) summary
    TIGR00930
    Location:3 → 351
    2a30; K-Cl cotransporter

  6. XM_006521822.4 → XP_006521885.1  solute carrier family 12 member 8 isoform X1

    See identical proteins and their annotated locations for XP_006521885.1

    Conserved Domains (1) summary
    TIGR00930
    Location:3 → 389
    2a30; K-Cl cotransporter

  7. XM_006521821.3 → XP_006521884.1  solute carrier family 12 member 8 isoform X1

    See identical proteins and their annotated locations for XP_006521884.1

    Conserved Domains (1) summary
    TIGR00930
    Location:3 → 389
    2a30; K-Cl cotransporter

  8. XM_006521827.3 → XP_006521890.1  solute carrier family 12 member 8 isoform X7

    UniProtKB/TrEMBL
    D3Z3V1
    Conserved Domains (1) summary
    TIGR00930
    Location:1 → 286
    2a30; K-Cl cotransporter

  9. XM_036159808.1 → XP_036015701.1  solute carrier family 12 member 8 isoform X8

    UniProtKB/TrEMBL
    D3Z3V1
    Related
    ENSMUSP00000113901.2, ENSMUST00000122314.8
    Conserved Domains (1) summary
    TIGR00930
    Location:11 → 186
    2a30; K-Cl cotransporter

  10. XM_030248994.2 → XP_030104854.1  solute carrier family 12 member 8 isoform X9

    UniProtKB/TrEMBL
    D3Z3V1
    Conserved Domains (1) summary
    TIGR00930
    Location:4 → 97
    2a30; K-Cl cotransporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VI23.2 GenPept UniProtKB/Swiss-Prot:Q8VI23

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