Foxd1 forkhead box D1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxd1provided by RGD
Official Full Name: forkhead box D1provided by RGD
Primary source: RGD:621712
See related: EnsemblRapid:ENSRNOG00000043332 AllianceGenome:RGD:621712
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BF-2; Hfhbf2
Summary: Predicted to enable DNA binding activity, bending; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including kidney development; luteinizing hormone secretion; and regulation of gene expression. Predicted to act upstream of or within axon guidance; branching involved in ureteric bud morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human FOXD1 (forkhead box D1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (31436802..31439222)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (29702558..29704978)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (28460068..28462488)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation.
Title: METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation.
Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP.
Title: Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP.

Submit: New GeneRIF Correction

General gene information

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Markers

AI385632 (e-PCR)
- UniSTS:165888

Foxd1 (e-PCR), detects polymorphism
- UniSTS:506899

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding, bending	IEA Inferred from Electronic Annotation more info
enables DNA binding, bending	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in dichotomous subdivision of terminal units involved in ureteric bud branching	IEA Inferred from Electronic Annotation more info
involved_in dichotomous subdivision of terminal units involved in ureteric bud branching	ISO Inferred from Sequence Orthology more info
involved_in dichotomous subdivision of terminal units involved in ureteric bud branching	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in luteinizing hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in luteinizing hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in metanephric capsule development	ISO Inferred from Sequence Orthology more info
involved_in metanephric capsule development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric capsule specification	IEA Inferred from Electronic Annotation more info
involved_in metanephric capsule specification	ISO Inferred from Sequence Orthology more info
involved_in metanephric capsule specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric nephron development	IEA Inferred from Electronic Annotation more info
involved_in metanephric nephron development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in nephrogenic mesenchyme development	IEA Inferred from Electronic Annotation more info
involved_in nephrogenic mesenchyme development	ISO Inferred from Sequence Orthology more info
involved_in pattern specification involved in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of kidney development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of kidney development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kidney development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: forkhead box protein D1

Names: brain factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134337.2 → NP_599164.2 forkhead box protein D1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

D3ZP43

Related

ENSRNOP00000060730.3, ENSRNOT00000066819.5

Conserved Domains (1) summary

cd20046
Location:130 → 228

FH_FOXD1_D2-like; Forkhead (FH) domain found in Forkhead box proteins FOXD1, FOXD2 and similar proteins