Ptprg protein tyrosine phosphatase, receptor type, G [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprgprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Gprovided by RGD
Primary source: RGD:620774
See related: EnsemblRapid:ENSRNOG00000009419 AllianceGenome:RGD:620774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ptpg
Summary: Predicted to enable identical protein binding activity and protein tyrosine phosphatase activity. Involved in negative regulation of neuron projection development. Located in extracellular space. Orthologous to human PTPRG (protein tyrosine phosphatase receptor type G). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 113.2), Adrenal (RPKM 106.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p15

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (15298669..15982581, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (12871706..13552186, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (12926056..13633839, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

both phosphacan and receptor protein tyrosine phosphatase beta splice variants participate in both the acute degenerative and long-term regenerative phases of reactive synaptogenesis
Title: Phosphacan and receptor protein tyrosine phosphatase β expression mediates deafferentation-induced synaptogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

D15Kyo1 (e-PCR), detects polymorphism
- UniSTS:518959

D15Got18 (e-PCR)
- UniSTS:115809

D15Rat136 (e-PCR), detects polymorphism
- UniSTS:226696

BE102252 (e-PCR)
- UniSTS:244107

BF390487 (e-PCR)
- UniSTS:249483

RH133004 (e-PCR)
- UniSTS:216287

BE116836 (e-PCR)
- UniSTS:248548

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	NAS Non-traceable Author Statement more info	PubMed
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in regulation of homophilic cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase gamma

Names: RPTP gamma A; RPTP gamma B; RPTP gamma C; RPTP gamma S; protein tyrosine phosphatase gamma; receptor-like protein tyrosine phosphatase gamma

NP_599183.2

EC 3.1.3.48

XP_063130015.1

EC 3.1.3.48

XP_063130016.1

EC 3.1.3.48

XP_063130017.1

EC 3.1.3.48

XP_063130018.1

EC 3.1.3.48

XP_063130019.1

EC 3.1.3.48

XP_063130020.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134356.2 → NP_599183.2 receptor-type tyrosine-protein phosphatase gamma

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

F1LP13, Q8CIN3

Related

ENSRNOP00000039045.6, ENSRNOT00000042010.7

Conserved Domains (4) summary

cd00063
Location:348 → 438

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd03122
Location:67 → 319

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

cd17667
Location:845 → 1118

R-PTPc-G-1; catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1

cd17670
Location:1202 → 1406

R-PTP-G-2; PTP-like domain of receptor-type tyrosine-protein phosphatase G, repeat 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

15298669..15982581 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273947.1 → XP_063130017.1 receptor-type tyrosine-protein phosphatase gamma isoform X3

UniProtKB/TrEMBL

A0A8I6A6D9

Related

ENSRNOP00000087710.1, ENSRNOT00000101353.2
XM_063273946.1 → XP_063130016.1 receptor-type tyrosine-protein phosphatase gamma isoform X2
XM_063273945.1 → XP_063130015.1 receptor-type tyrosine-protein phosphatase gamma isoform X1
XM_063273949.1 → XP_063130019.1 receptor-type tyrosine-protein phosphatase gamma isoform X5
XM_063273948.1 → XP_063130018.1 receptor-type tyrosine-protein phosphatase gamma isoform X4
XM_063273950.1 → XP_063130020.1 receptor-type tyrosine-protein phosphatase gamma isoform X6

UniProtKB/TrEMBL

A0A8I6ARJ1

Related

ENSRNOP00000095910.1, ENSRNOT00000099333.2