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Camk1g calcium/calmodulin-dependent protein kinase IG [ Rattus norvegicus (Norway rat) ]

Gene ID: 171358, updated on 27-Nov-2024

Summary

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Official Symbol
Camk1gprovided by RGD
Official Full Name
calcium/calmodulin-dependent protein kinase IGprovided by RGD
Primary source
RGD:621800
See related
EnsemblRapid:ENSRNOG00000006470 AllianceGenome:RGD:621800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium/calmodulin-dependent protein kinase activity. Involved in protein phosphorylation. Predicted to be located in endomembrane system and plasma membrane. Predicted to be part of calcium- and calmodulin-dependent protein kinase complex. Predicted to be active in cytoplasm. Orthologous to human CAMK1G (calcium/calmodulin dependent protein kinase IG). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 51.1), Lung (RPKM 8.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Camk1g in Genome Data Viewer
Location:
13q27
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (107406583..107430332, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (104877909..104901658, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (112075689..112099472, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene G0/G1switch 2 Neighboring gene laminin subunit beta 3 Neighboring gene microRNA 205 Neighboring gene uncharacterized LOC120096361

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase I gamma in the rat brain. Nishimura H, et al. J Neurochem, 2003 Jun. PMID 12753081
  2. Transient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neurons. Davare MA, et al. J Neurosci, 2009 Aug 5. PMID 19657032, Free PMC Article
  3. Isolation and comparison of rat cDNAs encoding Ca2+/calmodulin-dependent protein kinase I isoforms. Yokokura H, et al. Biochim Biophys Acta, 1997 Mar 7. PMID 9074610
  4. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). Takemoto-Kimura S, et al. J Biol Chem, 2003 May 16. PMID 12637513
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results are consistent with a model in which highly localized calcium influx through the TRPC5 channels activates CaMKK and CaMKI, which subsequently promote axon formation.
    Title: Transient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neurons.
  2. findings suggest that both alternatively splicing isoforms of CaMKI gamma may be involved in Ca2+ signal transduction in the cytoplasmic compartment of certain neuronal population
    Title: Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase I gamma in the rat brain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium/calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium/calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium-mediated signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of calcium- and calmodulin-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type 1G
Names
CLICK III
caM kinase I gamma
caM kinase IG
caM-KI gamma
caMK-like CREB kinase III
caMKI gamma
caMKIG
calcium/calmodulin-dependent protein kinase I gamma
NP_878262.1
XP_006250532.1
XP_063128062.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429714.1 → NP_001416643.1  calcium/calmodulin-dependent protein kinase type 1G isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6JH31

  2. NM_182842.1 → NP_878262.1  calcium/calmodulin-dependent protein kinase type 1G isoform 1

    See identical proteins and their annotated locations for NP_878262.1

    Status: PROVISIONAL

    Source sequence(s)
    AB101231
    UniProtKB/Swiss-Prot
    O08763, Q7TNJ6, Q7TNJ7
    UniProtKB/TrEMBL
    A6JH32
    Related
    ENSRNOP00000009158.3, ENSRNOT00000009158.8
    Conserved Domains (2) summary
    smart00220
    Location:23 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14166
    Location:19 → 303
    STKc_CaMKI_gamma; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    107406583..107430332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250470.4 → XP_006250532.1  calcium/calmodulin-dependent protein kinase type 1G isoform X2

    Related
    ENSRNOP00000041124.2, ENSRNOT00000044161.4
    Conserved Domains (2) summary
    smart00220
    Location:23 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14166
    Location:19 → 303
    STKc_CaMKI_gamma; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma

  2. XM_063271992.1 → XP_063128062.1  calcium/calmodulin-dependent protein kinase type 1G isoform X1

    UniProtKB/Swiss-Prot
    O08763, Q7TNJ6, Q7TNJ7
    UniProtKB/TrEMBL
    A6JH32
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNJ7.1 GenPept UniProtKB/Swiss-Prot:Q7TNJ7

Gene LinkOut

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