Nlrp6 NLR family, pyrin domain containing 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Nlrp6provided by RGD
Full Name: NLR family, pyrin domain containing 6provided by RGD
Primary source: RGD:708549
See related: EnsemblRapid:ENSRNOG00000045677 AllianceGenome:RGD:708549
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Avr; Navr; Nalp6; Non-AVR; Navr/Avr
Summary: The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. [provided by RefSeq, Feb 2013]
Expression: Restricted expression toward (RPKM 147.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205434484..205441245)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196004854..196011615)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (213676954..213683114)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peak expression of NLRP6 is in 48-h post-cerebral I/R injury. NRP6 has a pro-inflammatory effect in cerebral I/R injury
Title: Effects of NLRP6 in Cerebral Ischemia/Reperfusion (I/R) Injury in Rats.
AVR is distinct from Nalp6/PYPAF5 based on different mRNA and protein sizes, subcellular localization, and tissue-specific expression patterns.
Title: Overlapping genes in Nalp6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR.
The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model.
Title: The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model.
Transcripts of core components of NOD-like receptor Nlrp6 inflammasome (Nlrp6, Pycard, Caspase-1) and one of its substrates, IL-18, were increased at E20 compared with E16 in fetal intestine and not lung.
Title: Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipopolysaccharide binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipoteichoic acid binding	IEA Inferred from Electronic Annotation more info
enables lipoteichoic acid binding	ISO Inferred from Sequence Orthology more info
enables lipoteichoic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular condensate scaffold activity	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info
enables pattern recognition receptor activity	IEA Inferred from Electronic Annotation more info
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables vasopressin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasopressin receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in NLRP6 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
involved_in NLRP6 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in NLRP6 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in acute inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in acute inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acute inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in host-mediated regulation of intestinal microbiota composition	IEA Inferred from Electronic Annotation more info
NOT involved_in host-mediated regulation of intestinal microbiota composition	ISO Inferred from Sequence Orthology more info
involved_in host-mediated regulation of intestinal microbiota composition	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in necroptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in neutrophil-mediated killing of gram-positive bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil-mediated killing of gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-18-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-18-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyroptotic inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mucus secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mucus secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in wound healing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NLRP6 inflammasome complex	IEA Inferred from Electronic Annotation more info
part_of NLRP6 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of NLRP6 inflammasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of canonical inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of canonical inflammasome complex	IEA Inferred from Electronic Annotation more info
part_of canonical inflammasome complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 6

Names: NACHT, LRR and PYD domains-containing protein 6-like; NACHT, leucine rich repeat and PYD containing 6; angiotensin II/vasopressin receptor; dual angiotensin II/vasopressin receptor; non-angiotensin-vasopressin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134375.5 → NP_599202.4 NACHT, LRR and PYD domains-containing protein 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

A5X5C9, D3ZYC0, F1LSH2, Q63035

Related

ENSRNOP00000109810.1, ENSRNOT00000158943.1

Conserved Domains (5) summary

cd08321
Location:16 → 96

Pyrin_ASC-like; Pyrin Death Domain found in ASC

pfam05729
Location:195 → 348

NACHT; NACHT domain

pfam17776
Location:498 → 635

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:439 → 479

NOD2_WH; NOD2 winged helix domain

cl39015
Location:619 → 848

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...