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Tnnt1 troponin T1, slow skeletal type [ Rattus norvegicus (Norway rat) ]

Gene ID: 171409, updated on 27-Nov-2024

Summary

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Official Symbol
Tnnt1provided by RGD
Official Full Name
troponin T1, slow skeletal typeprovided by RGD
Primary source
RGD:621852
See related
EnsemblRapid:ENSRNOG00000028041 AllianceGenome:RGD:621852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
sTnT; tnTs; Fang2
Summary
Enables troponin T binding activity. Involved in slow-twitch skeletal muscle fiber contraction. Part of troponin complex. Human ortholog(s) of this gene implicated in nemaline myopathy 5A; nemaline myopathy 5B; and nemaline myopathy 5C. Orthologous to human TNNT1 (troponin T1, slow skeletal type). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 4333.7) See more
Orthologs
human mouse all
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Genomic context

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See Tnnt1 in Genome Data Viewer
Location:
1q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78349035..78359394)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69306362..69316721)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72889270..72899629)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, assembly factor 3 Neighboring gene troponin I3, cardiac type Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene EPS8-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression and functional properties of four slow skeletal troponin T isoforms in rat muscles. Kischel P, et al. Am J Physiol Cell Physiol, 2005 Aug. PMID 15788488
  2. Cellular fate of truncated slow skeletal muscle troponin T produced by Glu180 nonsense mutation in amish nemaline myopathy. Wang X, et al. J Biol Chem, 2005 Apr 8. PMID 15665378
  3. A novel nemaline myopathy in the Amish caused by a mutation in troponin T1. Johnston JJ, et al. Am J Hum Genet, 2000 Oct. PMID 10952871, Free PMC Article
  4. Alternative splicing generates variants in important functional domains of human slow skeletal troponin T. Gahlmann R, et al. J Biol Chem, 1987 Nov 25. PMID 2824479
  5. A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin. Pinto JR, et al. J Biol Chem, 2008 Jan 25. PMID 18032382

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tropomyosin binding ISO
Inferred from Sequence Orthology
more info
  
enables troponin T binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables troponin T binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in slow-twitch skeletal muscle fiber contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in slow-twitch skeletal muscle fiber contraction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within transition between fast and slow fiber ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
  
part_of troponin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
troponin T, slow skeletal muscle
Names
slow skeletal muscle troponin T
troponin T type 1 (skeletal, slow)
troponin T1, skeletal, slow

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277260.1 → NP_001264189.1  troponin T, slow skeletal muscle isoform 2

    See identical proteins and their annotated locations for NP_001264189.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AY334080, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KNL6
    Conserved Domains (1) summary
    pfam00992
    Location:67 → 203
    Troponin; Troponin

  2. NM_001277261.2 → NP_001264190.1  troponin T, slow skeletal muscle isoform 3

    See identical proteins and their annotated locations for NP_001264190.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AY334082, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KNL6
    Conserved Domains (1) summary
    pfam00992
    Location:56 → 192
    Troponin; Troponin

  3. NM_001277262.2 → NP_001264191.1  troponin T, slow skeletal muscle isoform 4

    See identical proteins and their annotated locations for NP_001264191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
    Source sequence(s)
    AY334081, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KNL6
    Related
    ENSRNOP00000055633.4, ENSRNOT00000058843.7
    Conserved Domains (1) summary
    pfam00992
    Location:57 → 193
    Troponin

  4. NM_134388.2 → NP_599215.2  troponin T, slow skeletal muscle isoform 1

    See identical proteins and their annotated locations for NP_599215.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AY334079, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q7TNA9, Q7TNB0, Q7TNB1, Q7TNB2, Q923S7
    UniProtKB/TrEMBL
    A6KNL6
    Related
    ENSRNOP00000038327.4, ENSRNOT00000034957.8
    Conserved Domains (1) summary
    pfam00992
    Location:68 → 204
    Troponin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    78349035..78359394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276629.1 → XP_063132699.1  troponin T, slow skeletal muscle isoform X1

  2. XM_063276722.1 → XP_063132792.1  troponin T, slow skeletal muscle isoform X5

  3. XM_063276740.1 → XP_063132810.1  troponin T, slow skeletal muscle isoform X6

  4. XM_063276683.1 → XP_063132753.1  troponin T, slow skeletal muscle isoform X3

  5. XM_063276702.1 → XP_063132772.1  troponin T, slow skeletal muscle isoform X4

  6. XM_063276768.1 → XP_063132838.1  troponin T, slow skeletal muscle isoform X7

  7. XM_063276789.1 → XP_063132859.1  troponin T, slow skeletal muscle isoform X8

  8. XM_063276811.1 → XP_063132881.1  troponin T, slow skeletal muscle isoform X9

  9. XM_063276664.1 → XP_063132734.1  troponin T, slow skeletal muscle isoform X2

  10. XM_063276839.1 → XP_063132909.1  troponin T, slow skeletal muscle isoform X10

    Related
    ENSRNOP00000076828.2, ENSRNOT00000101852.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNB2.3 GenPept UniProtKB/Swiss-Prot:Q7TNB2

Gene LinkOut

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