Zg16 zymogen granule protein 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zg16provided by RGD
Official Full Name: zymogen granule protein 16provided by RGD
Primary source: RGD:620346
See related: EnsemblRapid:ENSRNOG00000016857 AllianceGenome:RGD:620346
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zg16p; Zg-16p
Summary: Predicted to enable peptidoglycan binding activity. Predicted to be involved in protein transport. Predicted to act upstream of or within defense response to Gram-positive bacterium and suppression of symbiont entry into host. Located in zymogen granule membrane. Orthologous to human ZG16 (zymogen granule protein 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 1573.1) and Liver (RPKM 443.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191088248..191090605, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181657722..181660079, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198483800..198486157, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZG16p, an animal homolog of beta-prism fold plant lectins, interacts with heparan sulfate proteoglycans in pancreatic zymogen granules.
Title: ZG16p, an animal homolog of β-prism fold plant lectins, interacts with heparan sulfate proteoglycans in pancreatic zymogen granules.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within suppression of symbiont entry into host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi lumen	ISO Inferred from Sequence Orthology more info
located_in Golgi lumen	ISS Inferred from Sequence or Structural Similarity more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in mucus layer	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zymogen granule membrane protein 16

Names: secretory lectin ZG16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134409.2 → NP_599236.2 zymogen granule membrane protein 16 precursor

See identical proteins and their annotated locations for NP_599236.2

Status: VALIDATED

Source sequence(s)

AB095177, CF249177

UniProtKB/Swiss-Prot

Q63680, Q8CJD3

UniProtKB/TrEMBL

A6I9L1

Related

ENSRNOP00000022758.2, ENSRNOT00000022758.6

Conserved Domains (1) summary

cd09611
Location:31 → 158

Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins