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Nav2 neuron navigator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171563, updated on 4-Jan-2025

Summary

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Official Symbol
Nav2provided by RGD
Official Full Name
neuron navigator 2provided by RGD
Primary source
RGD:619778
See related
EnsemblRapid:ENSRNOG00000014530 AllianceGenome:RGD:619778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rainb1
Summary
Predicted to enable 3'-5' DNA helicase activity and heparin binding activity. Involved in nervous system development. Predicted to be located in interstitial matrix and nucleoplasm. Orthologous to human NAV2 (neuron navigator 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 118.4), Lung (RPKM 84.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nav2 in Genome Data Viewer
Location:
1q22
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (107799968..108458546)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (98957629..99322339)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (104575765..104941554)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene RAN, member RAS oncogene family, pseudogene 2 Neighboring gene uncharacterized LOC134483127 Neighboring gene uncharacterized LOC134483134 Neighboring gene uncharacterized LOC134484893 Neighboring gene developing brain homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos. Merrill RA, et al. Proc Natl Acad Sci U S A, 2002 Mar 19. PMID 11904404, Free PMC Article
  2. Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development. McNeill EM, et al. Dev Biol, 2011 May 15. PMID 21419114, Free PMC Article
  3. Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. Peeters PJ, et al. Brain Res Dev Brain Res, 2004 Jun 21. PMID 15158073
  4. Nav2 is necessary for cranial nerve development and blood pressure regulation. McNeill EM, et al. Neural Dev, 2010 Feb 25. PMID 20184720, Free PMC Article
  5. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos
    Title: A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glossopharyngeal nerve development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within optic nerve development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of systemic arterial blood pressure by baroreceptor feedback ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vagus nerve development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in interstitial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neuron navigator 2
Names
retinoic acid inducible in neuroblastoma cells 1
NP_612538.1
XP_017444230.1
XP_063134070.1
XP_063134105.1
XP_063134130.1
XP_063134159.1
XP_063134191.1
XP_063134221.1
XP_063134246.1
XP_063134274.1
XP_063134333.1
XP_063134353.1
XP_063134370.1
XP_063134395.1
XP_063134477.1
XP_063134528.1
XP_063134552.1
XP_063134601.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138529.1 → NP_612538.1  neuron navigator 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZQM9
    Related
    ENSRNOP00000074453.4, ENSRNOT00000078477.4
    Conserved Domains (4) summary
    smart00382
    Location:2087 → 2195
    AAA; ATPases associated with a variety of cellular activities
    cd00014
    Location:86 → 187
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam13401
    Location:2090 → 2177
    AAA_22; AAA domain
    pfam15898
    Location:1844 → 1896
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    107799968..108458546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278060.1 → XP_063134130.1  neuron navigator 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZQM9
    Related
    ENSRNOP00000106267.1, ENSRNOT00000156603.1

  2. XM_063278151.1 → XP_063134221.1  neuron navigator 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZQM9

  3. XM_017588741.3 → XP_017444230.1  neuron navigator 2 isoform X1

    UniProtKB/TrEMBL
    F1LR12
    Related
    ENSRNOP00000098226.1, ENSRNOT00000120586.2

  4. XM_063278000.1 → XP_063134070.1  neuron navigator 2 isoform X2

    UniProtKB/TrEMBL
    F1LR12
    Related
    ENSRNOP00000105628.1, ENSRNOT00000158547.1

  5. XM_063278035.1 → XP_063134105.1  neuron navigator 2 isoform X3

    UniProtKB/TrEMBL
    F1LR12
    Related
    ENSRNOP00000087383.3, ENSRNOT00000109728.3

  6. XM_063278204.1 → XP_063134274.1  neuron navigator 2 isoform X9

    UniProtKB/TrEMBL
    F1LR12
    Related
    ENSRNOP00000104067.1, ENSRNOT00000130191.1

  7. XM_063278121.1 → XP_063134191.1  neuron navigator 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A8E6

  8. XM_063278176.1 → XP_063134246.1  neuron navigator 2 isoform X8

    UniProtKB/TrEMBL
    A0A0G2K833, A0A8I6A8E6
    Related
    ENSRNOP00000098228.2, ENSRNOT00000120588.2

  9. XM_063278089.1 → XP_063134159.1  neuron navigator 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZQM9

  10. XM_063278263.1 → XP_063134333.1  neuron navigator 2 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZQM9

  11. XM_063278283.1 → XP_063134353.1  neuron navigator 2 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZQM9

  12. XM_063278300.1 → XP_063134370.1  neuron navigator 2 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZQM9

  13. XM_063278325.1 → XP_063134395.1  neuron navigator 2 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZQM9

  14. XM_063278407.1 → XP_063134477.1  neuron navigator 2 isoform X12

  15. XM_063278482.1 → XP_063134552.1  neuron navigator 2 isoform X13

  16. XM_063278458.1 → XP_063134528.1  neuron navigator 2 isoform X13

  17. XM_063278531.1 → XP_063134601.1  neuron navigator 2 isoform X14

RNA

  1. XR_010060052.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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