pgs-1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: pgs-1
Official Full Name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Primary source: WormBase:WBGene00021677
Locus tag: CELE_Y48G1C.4
See related: AllianceGenome:WB:WBGene00021677
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Involved in regulation of cell population proliferation and regulation of mitochondrial membrane potential. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiolipin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylglycerol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Preferred Names: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

NP_001364825.1

NP_490666.2

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