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lpr-1 LiPocalin-Related protein;Lipocln_cytosolic_FA-bd_dom domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171648, updated on 4-Jan-2025

Summary

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Official Symbol
lpr-1
Official Full Name
LiPocalin-Related protein;Lipocln_cytosolic_FA-bd_dom domain-containing protein
Primary source
WormBase:WBGene00002393
Locus tag
CELE_Y65B4BR.2
See related
AllianceGenome:WB:WBGene00002393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in nematode larval development and tube development. Predicted to be located in extracellular region. Is expressed in several structures, including P1; P10; P11; excretory system; and hypodermal cell. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lpr-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (557375..561671)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase wwp-1 Neighboring gene SSD domain-containing protein Neighboring gene ncRNA Neighboring gene Lipase_GDSL domain-containing protein Neighboring gene Homeobox protein ceh-9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lipocalins Are Required for Apical Extracellular Matrix Organization and Remodeling in Caenorhabditis elegans. Forman-Rubinsky R, et al. Genetics, 2017 Oct. PMID 28842397, Free PMC Article
  2. The Lipocalin LPR-1 Cooperates with LIN-3/EGF Signaling To Maintain Narrow Tube Integrity in Caenorhabditis elegans. Pu P, et al. Genetics, 2017 Mar. PMID 28040739, Free PMC Article
  3. Lipocalin signaling controls unicellular tube development in the Caenorhabditis elegans excretory system. Stone CE, et al. Dev Biol, 2009 May 15. PMID 19269285, Free PMC Article
  4. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen RC, et al. Mol Gen Genet, 2000 Mar. PMID 10778742
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lpr-1 is required to build a properly organized apical extracellular matrix in epithelial cells.
    Title: Lipocalins Are Required for Apical Extracellular Matrix Organization and Remodeling in Caenorhabditis elegans.
  2. LPR-1 is required to maintain apical membrane integrity and a continuous lumen in the excretory duct through a LIN-3/EGF-independent mechanism.
    Title: The Lipocalin LPR-1 Cooperates with LIN-3/EGF Signaling To Maintain Narrow Tube Integrity in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in lipid transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tube development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
LiPocalin-Related protein;Lipocln_cytosolic_FA-bd_dom domain-containing protein
NP_001293266.1
  • Confirmed by transcript evidence
NP_001293267.1
  • Confirmed by transcript evidence
NP_001293268.1
  • Confirmed by transcript evidence
NP_001293269.1
  • Confirmed by transcript evidence
NP_001293270.1
  • Confirmed by transcript evidence
NP_490752.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    557375..561671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058351.5 → NP_490752.2  Lipocln_cytosolic_FA-bd_dom domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490752.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEP5

  2. NM_001306339.3 → NP_001293268.1  LiPocalin-Related protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293268.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CKQ7

  3. NM_001306341.2 → NP_001293270.1  Lipocln_cytosolic_FA-bd_dom domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293270.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6DX33

  4. NM_001306340.3 → NP_001293269.1  Lipocln_cytosolic_FA-bd_dom domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293269.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6DX32

  5. NM_001306338.4 → NP_001293267.1  Lipocln_cytosolic_FA-bd_dom domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293267.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJJ4

  6. NM_001306337.3 → NP_001293266.1  Lipocln_cytosolic_FA-bd_dom domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293266.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLX5
    Conserved Domains (1) summary
    cl10502
    Location:53 → 187
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
Nucleotide Protein
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