mig-1 Frizzled-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mig-1
Official Full Name: Frizzled-4
Primary source: WormBase:WBGene00003238
Locus tag: CELE_Y34D9B.1
See related: AllianceGenome:WB:WBGene00003238
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in anal depressor muscle; head muscle; intestine; and neurons. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mig-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (948569..957456, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We find that VANG-1 promotes Wnt signaling by facilitating Frizzled endocytosis and genetically acts in a common pathway with arr-1/beta-arrestin, whose mutation results in defective PLM branching and F-actin patterns similar to those in the Wnt, mig-1 or vang-1 mutants
Title: A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y34D9B.a (e-PCR)
- UniSTS:324169

Y95B8A_85.a (e-PCR)
- UniSTS:324209

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of motor neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory neuron migration	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Frizzled-4

NP_001021744.1

Partially confirmed by transcript evidence

NP_490796.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

948569..957456 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026573.4 → NP_001021744.1 Frizzled-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021744.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9N532

Conserved Domains (2) summary

cl02447
Location:23 → 148

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

cl21561
Location:257 → 328

7tm_4; Olfactory receptor
NM_058395.6 → NP_490796.2 Frizzled-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490796.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EF44

Conserved Domains (2) summary

cl02447
Location:23 → 148

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

cl21561
Location:253 → 324

7tm_4; Olfactory receptor