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mab-20 Semaphorin-2A [ Caenorhabditis elegans ]

Gene ID: 171727, updated on 9-Dec-2024

Summary

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Official Symbol
mab-20
Official Full Name
Semaphorin-2A
Primary source
WormBase:WBGene00003111
Locus tag
CELE_Y71G12B.20
See related
AllianceGenome:WB:WBGene00003111
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables semaphorin receptor binding activity. Involved in several processes, including axon development; embryonic morphogenesis; and male anatomical structure morphogenesis. Located in cell surface. Is expressed in several structures, including linker cell; ray neurons; ray precursor cell; somatic nervous system; and vulval cell. Orthologous to human SEMA3B (semaphorin 3B) and SEMA3C (semaphorin 3C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mab-20 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (1644588..1651457, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Coiled-coil domain-containing protein Neighboring gene Mucin-5AC Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans. Ginzburg VE, et al. Development, 2002 May. PMID 11959817
  2. Semaphorin and Eph receptor signaling guide a series of cell movements for ventral enclosure in C. elegans. Ikegami R, et al. Curr Biol, 2012 Jan 10. PMID 22197242, Free PMC Article
  3. Semaphorin signaling restricts neuronal regeneration in C. elegans. Harreguy MB, et al. Front Cell Dev Biol, 2022. PMID 36325362, Free PMC Article
  4. mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans. Roy PJ, et al. Development, 2000 Feb. PMID 10648234
  5. The divergent C. elegans ephrin EFN-4 functions inembryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor. Chin-Sang ID, et al. Development, 2002 Dec. PMID 12403719

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EFN-4 and PLX-2 are coexpressed in the late embryonic epidermis where they play redundant roles in MAB-20-dependent cell sorting.
    Title: The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables semaphorin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode male tail mating organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell adhesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in semaphorin-plexin signaling pathway IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Semaphorin-2A
NP_001293443.1
  • Confirmed by transcript evidence
NP_001293444.1
  • Confirmed by transcript evidence
NP_490875.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1644588..1651457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058474.5 → NP_490875.1  Semaphorin-2A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490875.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86LT8, Q95XP4, Q9NI38, W6RTP3, W6SBL1
    Conserved Domains (3) summary
    smart00408
    Location:556 → 596
    IGc2; Immunoglobulin C-2 Type
    cd11238
    Location:34 → 477
    Sema_2A; The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A)
    pfam01437
    Location:478 → 521
    PSI; Plexin repeat

  2. NM_001306514.3 → NP_001293443.1  Semaphorin-2A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293443.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RTP3
    Conserved Domains (3) summary
    pfam01437
    Location:358 → 401
    PSI; Plexin repeat
    cl11960
    Location:435 → 472
    Ig; Immunoglobulin domain
    cl15693
    Location:1 → 357
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  3. NM_001306515.3 → NP_001293444.1  Semaphorin-2A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293444.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6SBL1
    Conserved Domains (3) summary
    pfam01437
    Location:301 → 344
    PSI; Plexin repeat
    cl11960
    Location:378 → 415
    Ig; Immunoglobulin domain
    cl15693
    Location:1 → 300
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RNA

  1. NR_165326.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95XP4.1

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