U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nsun-4 5-methylcytosine rRNA methyltransferase nsun-4 [ Caenorhabditis elegans ]

Gene ID: 171790, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
nsun-4
Official Full Name
5-methylcytosine rRNA methyltransferase nsun-4
Primary source
WormBase:WBGene00021476
Locus tag
CELE_Y39G10AR.21
See related
AllianceGenome:WB:WBGene00021476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables rRNA (cytosine-C5-)-methyltransferase activity and tRNA (cytidine-5-)-methyltransferase activity. Predicted to be involved in rRNA methylation and tRNA processing. Predicted to be located in mitochondrion. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See nsun-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (2308976..2312129)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Inner centromere protein ARK-binding domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Tubulin-specific chaperone A Neighboring gene protein-synthesizing GTPase Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The ribosomal RNA m(5)C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans. Heissenberger C, et al. Elife, 2020 Dec 8. PMID 33289480, Free PMC Article
  2. Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans. Navarro IC, et al. EMBO J, 2021 Mar 15. PMID 33283887, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (cytosine-C5-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA (cytidine-5-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
5-methylcytosine rRNA methyltransferase nsun-4
NP_001293364.1
  • Confirmed by transcript evidence
NP_001293365.1
  • Confirmed by transcript evidence
NP_490958.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2308976..2312129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058557.4 → NP_490958.1  5-methylcytosine rRNA methyltransferase nsun-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490958.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95XR2, X5LQ37, X5LVB3
    Conserved Domains (1) summary
    COG0144
    Location:234 → 394
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

  2. NM_001306435.3 → NP_001293364.1  5-methylcytosine rRNA methyltransferase nsun-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293364.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LVB3
    Conserved Domains (1) summary
    COG0144
    Location:145 → 305
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

  3. NM_001306436.3 → NP_001293365.1  5-methylcytosine rRNA methyltransferase nsun-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293365.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LQ37
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95XR2.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools