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itx-1 InTestinal NeureXin-like [ Caenorhabditis elegans ]

Gene ID: 171846, updated on 4-Jan-2025

Summary

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Official Symbol
itx-1
Official Full Name
InTestinal NeureXin-like
Primary source
WormBase:WBGene00002174
Locus tag
CELE_W03D8.6
See related
AllianceGenome:WB:WBGene00002174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Located in adherens junction and basolateral plasma membrane. Is expressed in anterior ganglion; intestine; spermatheca; and vulval muscle. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See itx-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
30
Sequence:
Chromosome: I; NC_003279.8 (2802803..2815830)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene Serine/threonine-protein phosphatase Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene Peptidase M23 Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The neurexin superfamily of Caenorhabditis elegans. Haklai-Topper L, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 21055481
  2. Identification of the hydrophobic glycoproteins of Caenorhabditis elegans. Fan X, et al. Glycobiology, 2005 Oct. PMID 15888633
  3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
InTestinal NeureXin-like
NP_001249244.2
  • Product from WormBase gene class itx;
    Partially confirmed by transcript evidence
NP_001249245.2
  • Product from WormBase gene class itx;
    Confirmed by transcript evidence
NP_001293382.1
  • Product from WormBase gene class itx;
    Confirmed by transcript evidence
NP_001293383.1
  • Product from WormBase gene class itx;
    Confirmed by transcript evidence
NP_001293384.1
  • Product from WormBase gene class itx;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2802803..2815830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306453.2 → NP_001293382.1  InTestinal NeureXin-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293382.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A078BS63
    Conserved Domains (3) summary
    cd00110
    Location:705 → 835
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:481 → 507
    EGF; EGF-like domain
    cl22861
    Location:1243 → 1339
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  2. NM_001262316.5 → NP_001249245.2  InTestinal NeureXin-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249245.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1ZUX6
    Conserved Domains (3) summary
    cd00110
    Location:705 → 835
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:481 → 507
    EGF; EGF-like domain
    cl22861
    Location:1243 → 1339
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  3. NM_001262315.4 → NP_001249244.2  InTestinal NeureXin-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249244.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45000
    Conserved Domains (3) summary
    cd00110
    Location:705 → 835
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:481 → 507
    EGF; EGF-like domain
    cl22861
    Location:1268 → 1364
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  4. NM_001306454.3 → NP_001293383.1  InTestinal NeureXin-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293383.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A078BPL3
    Conserved Domains (2) summary
    cd00110
    Location:538 → 668
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl22861
    Location:1076 → 1172
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

  5. NM_001306455.3 → NP_001293384.1  InTestinal NeureXin-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293384.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A078BPJ4
    Conserved Domains (2) summary
    cd00110
    Location:538 → 668
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl22861
    Location:1076 → 1172
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
Nucleotide Protein
Heading Accession and Version

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