pop-1 Protein pop-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pop-1
Official Full Name: Protein pop-1
Primary source: WormBase:WBGene00004077
Locus tag: CELE_W10C8.2
See related: AllianceGenome:WB:WBGene00004077
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including chordate pharyngeal muscle development; mesodermal cell fate commitment; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including QL; hypodermis; oocyte; somatic nervous system; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and reproductive organ cancer (multiple). Orthologous to several human genes including TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pop-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (2822243..2830311, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo.
Title: pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo.
RNT-1/BRO-1 appears to render POP-1 below the level required for its repressor function, which converts differentiation into self-renewal; conserved Runx/CBFbeta-type stem cell regulators switch asymmetric to proliferative cell division by opposing TCF-related transcriptional repression
Title: C. elegans Runx/CBFβ suppresses POP-1 TCF to convert asymmetric to proliferative division of stem cell-like seam cells.
these results indicate that SYS-1 and POP-1 levels are influenced by the parent cell's SYS-1/POP-1 levels and this may provide an additional mechanism by which POP-1 regulates distinct targets in different developmental contexts.
Title: Quantitative Differences in Nuclear β-catenin and TCF Pattern Embryonic Cells in C. elegans.
we demonstrate that POP-1 (the C. elegans TCF) also activates target genes through HMG and Helper site interactions.
Title: Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila.
SYS-1 and POP-1 nuclear levels are regulated in opposite directions; the C terminus of POP-1 is essential for LIT-1 phosphorylation and is specifically bound by the diverged beta-catenin WRM-1
Title: Distinct and mutually inhibitory binding by two divergent β-catenins coordinates TCF levels and activity in C. elegans.
Animals with reduced function of the Wnt-pathway downstream effector POP-1 have as many as 67 seam cells. The 'Wnt/beta-catenin asymmetry' pathway is required for the proper stem cell-like asymmetric division of seam cells.
Title: Wnt signaling controls the stem cell-like asymmetric division of the epithelial seam cells during C. elegans larval development.
Study suggests that pop-1 is not critical for mesoderm specification beyond repression of endoderm specification, and reveals that Wnt-modified pop-1 further reinforces endoderm specification by repressing mesoderm fate in endoderm.
Title: Roles of the Wnt effector POP-1/TCF in the C. elegans endomesoderm specification gene network.
Integration of Wnt-dependent and Wnt-independent cell fate specification pathways within the Caenorhabditis genus can occur in different ways.
Title: Knockdown of SKN-1 and the Wnt effector TCF/POP-1 reveals differences in endomesoderm specification in C. briggsae as compared with C. elegans.
There are two genetic pathways, one increasing SYS-1 and the other decreasing POP-1 levels, robustly elevate the SYS-1-to-POP-1 ratio in the posterior cell, thereby driving A-P differential cell fates.
Title: Binary cell fate specification during C. elegans embryogenesis driven by reiterated reciprocal asymmetry of TCF POP-1 and its coactivator beta-catenin SYS-1.
acetylation enhances nuclear retention of POP-1, the Caenorhabditis elegans LEF/TCF homolog, through increasing nuclear import and blocking nuclear export
Title: Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W03D8.4 (e-PCR)
- UniSTS:318585

W10C8.2 (e-PCR)
- UniSTS:319732

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chordate pharyngeal muscle development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chordate pharyngeal muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesodermal cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of proximal/distal axis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of asymmetric cell division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of defecation rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein pop-1

NP_491053.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

2822243..2830311 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058652.5 → NP_491053.4 Protein pop-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491053.4

Status: REVIEWED

UniProtKB/Swiss-Prot

O45007, Q10666

Conserved Domains (1) summary

cd01388
Location:191 → 264

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...