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dnc-5 Dynactin subunit 5 [ Caenorhabditis elegans ]

Gene ID: 171856, updated on 2-Nov-2024

Summary

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Official Symbol
dnc-5
Official Full Name
Dynactin subunit 5
Primary source
WormBase:WBGene00022118
Locus tag
CELE_Y71F9AL.14
See related
AllianceGenome:WB:WBGene00022118
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Part of dynactin complex. Is expressed in nervous system. Orthologous to human DCTN5 (dynactin subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dnc-5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (2880876..2883454, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CUE domain-containing protein Neighboring gene Myb_DNA-bind_3 domain-containing protein Neighboring gene Actin-related protein 3 Neighboring gene Ovule protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insights on UNC-104-dynein/dynactin interactions and their implications on axonal transport in Caenorhabditis elegans. Chen CW, et al. J Neurosci Res, 2019 Feb. PMID 30311677
  2. Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Terasawa M, et al. Genes Cells, 2010 Nov. PMID 20964796, Free PMC Article
  3. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Dynactin subunit 5
NP_001380049.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2880876..2883454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393141.1 → NP_001380049.1  Dynactin subunit 5 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4I1
    Conserved Domains (1) summary
    cd03359
    Location:13 → 173
    LbH_Dynactin_5; Dynactin 5 (or subunit p25); Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
Nucleotide Protein
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