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trap-1 Translocon-associated protein subunit alpha [ Caenorhabditis elegans ]

Gene ID: 171865, updated on 4-Jan-2025

Summary

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Official Symbol
trap-1
Official Full Name
Translocon-associated protein subunit alpha
Primary source
WormBase:WBGene00022122
Locus tag
CELE_Y71F9AM.6
See related
AllianceGenome:WB:WBGene00022122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SSR1 (signal sequence receptor subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See trap-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (2928395..2929628)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1 Neighboring gene ncRNA Neighboring gene tRNA (guanine(10)-N2)-methyltransferase homolog Neighboring gene NTF2-related export protein Neighboring gene Conserved oligomeric Golgi complex subunit 3;Conserved oligomeric Golgi complex subunit 3 C-terminal domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular basis of the TRAP complex function in ER protein biogenesis. Jaskolowski M, et al. Nat Struct Mol Biol, 2023 Jun. PMID 37170030, Free PMC Article
  2. Hsp90 and its mitochondrial homologue TRAP-1 independently regulate hypoxia adaptations in Caenorhabditis elegans. Pant A, et al. Mitochondrion, 2021 Sep. PMID 34365052
  3. Requirement for translocon-associated protein (TRAP) α in insulin biogenesis. Li X, et al. Sci Adv, 2019 Dec. PMID 31840061, Free PMC Article
  4. Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans. Hammerquist AM, et al. Sci Rep, 2020 Nov 9. PMID 33168938, Free PMC Article
  5. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Translocon-associated protein subunit alpha
NP_491076.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2928395..2929628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058675.6 → NP_491076.1  Translocon-associated protein subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491076.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95XT5
    Conserved Domains (1) summary
    pfam03896
    Location:16 → 251
    TRAP_alpha; Translocon-associated protein (TRAP), alpha subunit
Nucleotide Protein
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