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nobh-1 RNA-binding protein NOB1 [ Caenorhabditis elegans ]

Gene ID: 171874, updated on 9-Dec-2024

Summary

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Official Symbol
nobh-1
Official Full Name
RNA-binding protein NOB1
Primary source
WormBase:WBGene00021843
Locus tag
CELE_Y54E10BR.4
See related
AllianceGenome:WB:WBGene00021843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA endonuclease activity. Predicted to be involved in maturation of SSU-rRNA. Located in cytoplasm. Is expressed in neurons. Orthologous to human NOB1 (NIN1 (RPN12) binding protein 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nobh-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (3015742..3021535)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Dual specificity mitogen-activated protein kinase kinase mek-2 Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene RING-type E3 ubiquitin transferase Neighboring gene Signal peptidase complex catalytic subunit SEC11 Neighboring gene ADP-ribosylation factor-related protein 1 Neighboring gene DNA-directed RNA polymerase II subunit RPB7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. van Haaften G, et al. Curr Biol, 2006 Jul 11. PMID 16824923
  2. Lifespan regulation by evolutionarily conserved genes essential for viability. Curran SP, et al. PLoS Genet, 2007 Apr 6. PMID 17411345, Free PMC Article
  3. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
  4. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373
  5. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein NOB1
NP_001411906.1
  • Confirmed by transcript evidence
NP_491090.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3015742..3021535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058689.6 → NP_491090.1  RNA-binding protein NOB1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491090.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N3D3
    Conserved Domains (2) summary
    pfam08772
    Location:224 → 295
    NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like
    pfam17146
    Location:11 → 97
    PIN_6; PIN domain of ribonuclease

  2. NM_001424977.1 → NP_001411906.1  RNA-binding protein NOB1 [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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