U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nhr-64 Nuclear hormone receptor family member nhr-64 [ Caenorhabditis elegans ]

Gene ID: 171884, updated on 9-Dec-2024

Summary

Official Symbol
nhr-64
Official Full Name
Nuclear hormone receptor family member nhr-64
Primary source
WormBase:WBGene00003654
Locus tag
CELE_C45E1.1
See related
AllianceGenome:WB:WBGene00003654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in hypodermis; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See nhr-64 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (3101983..3109530)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase RIO1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FBA_2 domain-containing protein Neighboring gene DUF148 domain-containing protein Neighboring gene ncRNA

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Nuclear hormone receptor family member nhr-64
NP_001021042.2
  • Confirmed by transcript evidence
NP_001021043.2
  • Confirmed by transcript evidence
NP_001343721.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3101983..3109530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356801.3NP_001343721.1  Nuclear hormone receptor family member nhr-64 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C2W7
    Conserved Domains (2) summary
    cd06960
    Location:33108
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    cl11397
    Location:132354
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. NM_001025871.7NP_001021042.2  Nuclear hormone receptor family member nhr-64 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021042.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D4YW56, D4YW57, O44960, Q688B5, Q86PK4, Q86PK5, Q86PK6
    Conserved Domains (2) summary
    cd06960
    Location:27102
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    cl11397
    Location:126348
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  3. NM_001025872.7NP_001021043.2  Nuclear hormone receptor family member nhr-64 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021043.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44960
    Conserved Domains (2) summary
    cd06960
    Location:2777
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    cl11397
    Location:101323
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators