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cdap-2 SH3 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171906, updated on 2-Nov-2024

Summary

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Official Symbol
cdap-2
Official Full Name
SH3 domain-containing protein
Primary source
WormBase:WBGene00021549
Locus tag
CELE_Y44E3A.4
See related
AllianceGenome:WB:WBGene00021549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in actin filament organization and cell migration. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 3; and immunodeficiency 61. Orthologous to several human genes including CD2AP (CD2 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cdap-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (3318830..3330673, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Carboxylic ester hydrolase Neighboring gene Uncharacterized protein Neighboring gene Thioredoxin Neighboring gene Creatinase_N domain-containing protein;Hydrolase;Uncharacterized protein Neighboring gene FHA domain-containing protein Neighboring gene Hyphal_reg_CWP domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
  2. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article
  3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SH3 domain-containing protein
NP_491143.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3318830..3330673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058742.6 → NP_491143.3  SH3 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491143.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6A573
    Conserved Domains (1) summary
    cl17036
    Location:194 → 249
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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Gene LinkOut

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