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jmjc-1 Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [ Caenorhabditis elegans ]

Gene ID: 171932, updated on 9-Dec-2024

Summary

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Official Symbol
jmjc-1
Official Full Name
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
Primary source
WormBase:WBGene00020902
Locus tag
CELE_T28F2.4
See related
AllianceGenome:WB:WBGene00020902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable histone H3K36 demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; and iron ion binding activity. Involved in several processes, including response to ethanol; response to heat; and response to osmotic stress. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human RIOX1 (ribosomal oxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See jmjc-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (3631091..3636485, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Seven cysteines N-terminal domain-containing protein Neighboring gene Carbonic anhydrase Neighboring gene Protein LAZ1;Vacuolar protein sorting-associated protein 13D Neighboring gene tRNA-Met

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The conserved PBAF nucleosome-remodeling complex mediates the response to stress in Caenorhabditis elegans. Kuzmanov A, et al. Mol Cell Biol, 2014 Mar. PMID 24421384, Free PMC Article
  2. Box C/D small nucleolar ribonucleoproteins regulate mitochondrial surveillance and innate immunity. Tjahjono E, et al. PLoS Genet, 2022 Mar. PMID 35275914, Free PMC Article
  3. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
  4. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806
  5. SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network. Kirienko NV, et al. EMBO J, 2010 Feb 17. PMID 20057358, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K36 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K36 demethylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3K36me/H3K36me2 demethylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K4 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
NP_001021644.1
  • Confirmed by transcript evidence
NP_001021645.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3631091..3636485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026473.7 → NP_001021644.1  Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021644.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G8XYY5, O01658
    Conserved Domains (1) summary
    pfam08007
    Location:317 → 662
    Cupin_4; Cupin superfamily protein

  2. NM_001026474.4 → NP_001021645.1  Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021645.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01658
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01658.2

Gene LinkOut

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