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rab-8 Ras-related protein Rab-8A [ Caenorhabditis elegans ]

Gene ID: 171935, updated on 9-Dec-2024

Summary

Official Symbol
rab-8
Official Full Name
Ras-related protein Rab-8A
Primary source
WormBase:WBGene00004272
Locus tag
CELE_D1037.4
See related
AllianceGenome:WB:WBGene00004272
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTPase activating protein binding activity and ankyrin repeat binding activity. Involved in several processes, including embryonic genitalia morphogenesis; negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and protein secretion. Located in apical cortex; apical plasma membrane; and cytoplasmic vesicle. Is expressed in body wall musculature and intestine. Orthologous to several human genes including RAB8B (RAB8B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See rab-8 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (3682890..3684086, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Sema domain-containing protein Neighboring gene Ferritin Neighboring gene Protein SON Neighboring gene phospholipase A2 Neighboring gene DNA mismatch repair proteins mutS family domain-containing protein

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables ankyrin repeat binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in apical cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in trans-Golgi network transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Ras-related protein Rab-8A
NP_491199.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3682890..3684086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058798.9NP_491199.2  Ras-related protein Rab-8A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491199.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFC1, I7F493
    Conserved Domains (2) summary
    smart00175
    Location:9172
    RAB; Rab subfamily of small GTPases
    cd01867
    Location:6172
    Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)