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pmlr-1 FHA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171946, updated on 23-Jan-2025

Summary

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Official Symbol
pmlr-1
Official Full Name
FHA domain-containing protein
Primary source
WormBase:WBGene00016323
Locus tag
CELE_C32E8.5
See related
AllianceGenome:WB:WBGene00016323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in miRNA processing. Predicted to be active in nucleus. Orthologous to human SNIP1 (Smad nuclear interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pmlr-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (3782118..3783294)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene AMP-binding domain-containing protein;AMP-dependent synthetase/ligase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Resistance to inhibitors of cholinesterase protein 19 Neighboring gene Uncharacterized protein Neighboring gene Tubulin polymerization-promoting protein homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Simmer F, et al. Curr Biol, 2002 Aug 6. PMID 12176360
  2. Automated profiling of gene function during embryonic development. Green RA, et al. Cell, 2024 Jun 6. PMID 38759650,
  3. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FHA domain-containing protein
NP_491217.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3782118..3783294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058816.5 → NP_491217.1  FHA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491217.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91125
    Conserved Domains (1) summary
    cd00060
    Location:165 → 277
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
Nucleotide Protein
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