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gsp-4 Serine/threonine-protein phosphatase PP1-delta [ Caenorhabditis elegans ]

Gene ID: 171960, updated on 4-Jan-2025

Summary

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Official Symbol
gsp-4
Official Full Name
Serine/threonine-protein phosphatase PP1-delta
Primary source
WormBase:WBGene00020187
Locus tag
CELE_T03F1.5
See related
AllianceGenome:WB:WBGene00020187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine phosphatase activity. Involved in several processes, including amoeboid sperm motility; egg-laying behavior; and male meiosis chromosome segregation. Located in chromatin; cytoplasm; and pseudopodium. Is expressed in IL socket cell; anal sphincter muscle; germ line; intestine; and sperm. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See gsp-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (3838290..3839673, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 234 homolog Neighboring gene ncRNA Neighboring gene AntiZyme INhibitor;Antizyme inhibitor 1;BRCA1 Neighboring gene Coiled-coil domain-containing protein 102A Neighboring gene F-box domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene Dimethyladenosine transferase 1, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sperm Affects Head Sensory Neuron in Temperature Tolerance of Caenorhabditis elegans. Sonoda S, et al. Cell Rep, 2016 Jun 28. PMID 27320929
  2. Characterization of a Caenorhabditis elegans glc seven-like phosphatase (gsp) orthologue from Haemonchus contortus (Nematoda). Campbell BE, et al. Mol Cell Probes, 2010 Aug. PMID 20153820
  3. Molecular characterisation of a male-specific serine/threonine phosphatase from Oesophagostomum dentatum (Nematoda: Strongylida), and functional analysis of homologues in Caenorhabditis elegans. Boag PR, et al. Int J Parasitol, 2003 Mar. PMID 12670516
  4. Maternal MEMI Promotes Female Meiosis II in Response to Fertilization in Caenorhabditis elegans. Ataeian M, et al. Genetics, 2016 Dec. PMID 27729423, Free PMC Article
  5. Sperm-specific glycogen synthase kinase 3 is required for sperm motility and the post-fertilization signal for female meiosis II in Caenorhabditis elegans. Banerjee RP, et al. Development, 2022 May 15. PMID 35635101

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amoeboid sperm motility IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in egg-laying behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in male meiosis chromosome segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of pseudopodium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pseudopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pseudopodium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serine/threonine-protein phosphatase PP1-delta
NP_001379823.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3838290..3839673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393293.1 → NP_001379823.1  Serine/threonine-protein phosphatase PP1-delta [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91420
    Conserved Domains (1) summary
    cl13995
    Location:6 → 297
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91420.1

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