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lin-44 Abnormal cell lineage protein 44 [ Caenorhabditis elegans ]

Gene ID: 171994, updated on 2-Nov-2024

Summary

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Official Symbol
lin-44
Official Full Name
Abnormal cell lineage protein 44
Primary source
WormBase:WBGene00003029
Locus tag
CELE_E01A2.3
See related
AllianceGenome:WB:WBGene00003029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cytokine activity and frizzled binding activity. Involved in several processes, including nematode male tail tip morphogenesis; neuron migration; and positive regulation of cell projection organization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including P6.pa; anchor cell; hypodermis; rectal epithelial cell; and tail. Human ortholog(s) of this gene implicated in ectodermal dysplasia (multiple); obesity; oral squamous cell carcinoma; split hand-foot malformation 6; and tooth agenesis. Orthologous to several human genes including WNT10A (Wnt family member 10A); WNT10B (Wnt family member 10B); and WNT11 (Wnt family member 11). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lin-44 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (4126056..4129310)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Basic proline-rich protein Neighboring gene NF-kappa-B-activating protein C-terminal domain-containing protein Neighboring gene Serrate RNA effector molecule homolog Neighboring gene Diphthine--ammonia ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. Sawa H, et al. Genes Dev, 1996 Sep 1. PMID 8804313
  2. C. elegans fmi-1/flamingo and Wnt pathway components interact genetically to control the anteroposterior neurite growth of the VD GABAergic neurons. Huarcaya Najarro E, et al. Dev Biol, 2013 May 1. PMID 23376536, Free PMC Article
  3. Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans. Lu M, et al. Elife, 2019 Dec 5. PMID 31804181, Free PMC Article
  4. Mutations in the Caenorhabditis elegans gene vab-3 reveal distinct roles in fate specification and unequal cytokinesis in an asymmetric cell division. Chamberlin HM, et al. Dev Biol, 1995 Aug. PMID 7649393
  5. TLP-1 is an asymmetric cell fate determinant that responds to Wnt signals and controls male tail tip morphogenesis in C. elegans. Zhao X, et al. Development, 2002 Mar. PMID 11880358

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LIN-17 and DSH-1/Dishevelled proteins were recruited to the pruning neurites in lin-44-dependent manners.
    Title: Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans.
  2. The Wnt ligand lin-44 contributes to the early stages of gastrulation in parallel to sdn-1, but in a genetic pathway with ptp-3.
    Title: A Synthetic Lethal Screen Identifies a Role for Lin-44/Wnt in C. elegans Embryogenesis.
  3. In sensory neurons, the posteriorly enriched LIN-44/Wnt acts as a repellent to promote anteriorly directed neurite outgrowth through the LIN-17/Frizzled receptor, instead of controlling neuronal polarity as previously thought.
    Title: Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans.
  4. our results strongly suggest that functions of at least four Wnts (lin-44, cwn-1, cwn-2, and egl-20) determine the polarity orientation of seam cells
    Title: Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells.
  5. LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans Neurons.
    Title: LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans Neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables receptor ligand activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in asymmetric cell division IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate specification involved in pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in generation of neurons IEA
Inferred from Electronic Annotation
more info
  
involved_in interneuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in motor neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of motor neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in programmed cell death involved in cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Abnormal cell lineage protein 44
NP_001021081.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4126056..4129310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025910.5 → NP_001021081.1  Abnormal cell lineage protein 44 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021081.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27886, Q6F3D0
    Conserved Domains (1) summary
    smart00097
    Location:64 → 339
    WNT1; found in Wnt-1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27886.1

Gene LinkOut

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