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nrd-1 CID domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172064, updated on 4-Jan-2025

Summary

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Official Symbol
nrd-1
Official Full Name
CID domain-containing protein
Primary source
WormBase:WBGene00017004
Locus tag
CELE_D1007.7
See related
AllianceGenome:WB:WBGene00017004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Is expressed in several structures, including excretory cell; hypodermis; pharyngeal-intestinal valve; rectal gland cell; and reproductive system. Orthologous to several human genes including SCAF4 (SR-related CTD associated factor 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nrd-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (4597923..4602666, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene 7TM_GPCR_Srx domain-containing protein;Gustatory receptor;PH domain-containing protein Neighboring gene Secreted protein Neighboring gene Ell-associated factor Eaf Neighboring gene Nucleic acid-binding, OB-fold protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin. LaBella ML, et al. Dev Cell, 2020 Jan 6. PMID 31910362, Free PMC Article
  2. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
  3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CID domain-containing protein
NP_491403.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4597923..4602666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059002.7 → NP_491403.1  CID domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491403.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01864
    Conserved Domains (5) summary
    smart00582
    Location:8 → 136
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:524 → 597
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12227
    Location:523 → 599
    RRM_SCAF4_SCAF8; RNA recognition motif in SR-related and CTD-associated factor 4 (SCAF4), SR-related and CTD-associated factor 8 (SCAF8) and similar proteins
    pfam04554
    Location:740 → 787
    Extensin_2; Extensin-like region
    pfam06346
    Location:738 → 787
    Drf_FH1; Formin Homology Region 1
Nucleotide Protein
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