let-502 Rho-associated protein kinase let-502 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: let-502
Official Full Name: Rho-associated protein kinase let-502
Primary source: WormBase:WBGene00002694
Locus tag: CELE_C10H11.9
See related: AllianceGenome:WB:WBGene00002694
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable Rho-dependent protein serine/threonine kinase activity. Involved in several processes, including embryonic body morphogenesis; nematode pharyngeal gland morphogenesis; and nematode pharynx development. Located in adherens junction; contractile muscle fiber; and nucleus. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; hypodermis; reproductive system; and tail. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1) and ROCK2 (Rho associated coiled-coil containing protein kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See let-502 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (4738171..4744321, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LET-502/ROCK Regulates Endocytic Recycling by Promoting Activation of RAB-5 in a Distinct Subpopulation of Sorting Endosomes.
Title: LET-502/ROCK Regulates Endocytic Recycling by Promoting Activation of RAB-5 in a Distinct Subpopulation of Sorting Endosomes.
MLC-4-containing myosin II is a Rho GTPase-regulated generator of contractility (of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad) and that the two myosin II populations coordinate to produce actomyosin contractility for successful ovulation.
Title: Two distinct myosin II populations coordinate ovulatory contraction of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad.
RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. elegans
Title: The Rho guanine exchange factor RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. elegans.
pix-1 has a role in controlling early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans
Title: pix-1 controls early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans.
Data show that combined loss of ROCK and PAK, or ROCK and MRCK, completely prevented embryonic elongation, but a constitutively active form of MLC-4 could only rescue a lack of MRCK.
Title: Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles.
actomyosin-generated tension must be moderated in two out of the three sets of epidermal cells surrounding the C. elegans embryo to achieve morphogenesis
Title: The RhoGAP RGA-2 and LET-502/ROCK achieve a balance of actomyosin-dependent forces in C. elegans epidermis to control morphogenesis.
Data describe nonmuscle myosins nmy-1 and nmy-2, which are components of the let-502/mel-11 pathway and assist in regulation of embryo elongation in C. elegans.
Title: The Caenorhabditis elegans nonmuscle myosin genes nmy-1 and nmy-2 function as redundant components of the let-502/Rho-binding kinase and mel-11/myosin phosphatase pathway during embryonic morphogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C10H11.9 (e-PCR)
- UniSTS:308536

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rho protein signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in contractile muscle fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Rho-associated protein kinase let-502

NP_491440.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4738171..4744321 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059039.8 → NP_491440.1 Rho-associated protein kinase let-502 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491440.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P92199

Conserved Domains (4) summary

smart00109
Location:1060 → 1112

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00220
Location:68 → 330

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl17171
Location:951 → 1056

PH-like; Pleckstrin homology-like domain

cl21453
Location:41 → 393

PKc_like; Protein Kinases, catalytic domain