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ept-1 EthanolaminePhosphoTransferase 1 homolog [ Caenorhabditis elegans ]

Gene ID: 172097, updated on 9-Dec-2024

Summary

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Official Symbol
ept-1
Official Full Name
EthanolaminePhosphoTransferase 1 homolog
Primary source
WormBase:WBGene00018797
Locus tag
CELE_F54D7.2
See related
AllianceGenome:WB:WBGene00018797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ethanolaminephosphotransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum membrane. Is expressed in body wall musculature; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 81. Orthologous to human SELENOI (selenoprotein I). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ept-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (4805607..4809674)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Zwei Ig domain protein zig-7 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Twenty One u-rna (21U-RNA) biogenesis Fouled Up Neighboring gene HORMA domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Choe KP, et al. Am J Physiol Cell Physiol, 2008 Dec. PMID 18829898, Free PMC Article
  2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ethanolaminephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EthanolaminePhosphoTransferase 1 homolog
NP_491454.2
  • Confirmed by transcript evidence;
    Product from WormBase gene class ept

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4805607..4809674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059053.7 → NP_491454.2  EthanolaminePhosphoTransferase 1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491454.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44732
    Conserved Domains (1) summary
    cl00453
    Location:27 → 386
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
Nucleotide Protein
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