U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

app-1 Xaa-Pro aminopeptidase app-1 [ Caenorhabditis elegans ]

Gene ID: 172118, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
app-1
Official Full Name
Xaa-Pro aminopeptidase app-1
Primary source
WormBase:WBGene00000155
Locus tag
CELE_W03G9.4
See related
AllianceGenome:WB:WBGene00000155
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables metalloaminopeptidase activity; protein homodimerization activity; and zinc ion binding activity. Involved in proteolysis involved in protein catabolic process. Located in cytoplasm. Is expressed in intestine. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to several human genes including XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See app-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (4964667..4967089, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ENhancer of Uncoordination Neighboring gene Protein pid-4 Neighboring gene Protein kinase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site. Iyer S, et al. FEBS Open Bio, 2015. PMID 25905034, Free PMC Article
  2. Functional expression and characterization of the cytoplasmic aminopeptidase P of Caenorhabditis elegans. Laurent V, et al. Eur J Biochem, 2001 Oct. PMID 11606206
  3. Proline-specific aminopeptidase P prevents replication-associated genome instability. Silva N, et al. PLoS Genet, 2022 Jan. PMID 35081133, Free PMC Article
  4. Intrinsically disordered protein PID-2 modulates Z granules and is required for heritable piRNA-induced silencing in the Caenorhabditis elegans embryo. Placentino M, et al. EMBO J, 2021 Feb 1. PMID 33231880, Free PMC Article
  5. PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins. Hsieh HC, et al. Autophagy, 2024 Jun. PMID 38261662, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proline-specific aminopeptidase P prevents replication-associated genome instability.
    Title: Proline-specific aminopeptidase P prevents replication-associated genome instability.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Xaa-Pro aminopeptidase app-1
NP_491489.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4964667..4967089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059088.8 → NP_491489.1  Xaa-Pro aminopeptidase app-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491489.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44750
    Conserved Domains (4) summary
    cd01085
    Location:325 → 547
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:552 → 616
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:159 → 322
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:54 → 141
    Creatinase_N; Creatinase/Prolidase N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44750.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools