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vha-16 V-type proton ATPase subunit [ Caenorhabditis elegans ]

Gene ID: 172134, updated on 4-Jan-2025

Summary

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Official Symbol
vha-16
Official Full Name
V-type proton ATPase subunit
Primary source
WormBase:WBGene00016258
Locus tag
CELE_C30F8.2
See related
AllianceGenome:WB:WBGene00016258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in vacuolar acidification and vacuolar transport. Predicted to be part of plasma membrane proton-transporting V-type ATPase complex and vacuolar proton-transporting V-type ATPase complex. Predicted to be active in early endosome. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and vulval muscle. Orthologous to several human genes including ATP6V0D1 (ATPase H+ transporting V0 subunit d1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See vha-16 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (5079910..5082279, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene FH1/FH2 domain-containing protein 3;FH1/FH2 domain-containing protein 3-like;Formin HOmology Domain Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Inactive tyrosine-protein kinase kin-32 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons. Yang Y, et al. Nat Aging, 2024 Feb. PMID 38177330, Free PMC Article
  2. Variants in ATP6V0A1 cause progressive myoclonus epilepsy and developmental and epileptic encephalopathy. Bott LC, et al. Brain Commun, 2021. PMID 34909687, Free PMC Article
  3. Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity. Yu Y, et al. Elife, 2024 Jan 19. PMID 38240316, Free PMC Article
  4. An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development. Miao R, et al. Dev Cell, 2020 Jan 6. PMID 31735670
  5. SAFER, an Analysis Method of Quantitative Proteomic Data, Reveals New Interactors of the C. elegans Autophagic Protein LGG-1. Yi Z, et al. J Proteome Res, 2016 May 6. PMID 26999449

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of plasma membrane proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
V-type proton ATPase subunit
NP_491515.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5079910..5082279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059114.8 → NP_491515.2  V-type proton ATPase subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491515.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95YD5
    Conserved Domains (2) summary
    COG1527
    Location:11 → 348
    NtpC; Archaeal/vacuolar-type H+-ATPase subunit C/Vma6 [Energy production and conversion]
    pfam01992
    Location:13 → 336
    vATP-synt_AC39; ATP synthase (C/AC39) subunit
Nucleotide Protein
Heading Accession and Version

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