sem-2 Transcription factor sem-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sem-2
Official Full Name: Transcription factor sem-2
Primary source: WormBase:WBGene00004771
Locus tag: CELE_C32E12.5
See related: AllianceGenome:WB:WBGene00004771
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell fate specification; positive regulation of egg-laying behavior; and positive regulation of vulval development. Located in nucleus. Is expressed in several structures, including E lineage cell; M.vlpaapa nucleus; RMH; blast cell; and body wall muscle cell from M lineage. Human ortholog(s) of this gene implicated in several diseases, including Coffin-Siris syndrome (multiple); hypotrichosis-lymphedema-telangiectasia syndrome; hypotrichosis-lymphedema-telangiectasia-renal defect syndrome; patent ductus arteriosus; and vesicoureteral reflux. Orthologous to several human genes including SOX11 (SRY-box transcription factor 11); SOX17 (SRY-box transcription factor 17); and SOX18 (SRY-box transcription factor 18). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sem-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (5204530..5208128, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm.
Title: The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in mesodermal cell fate specification	IDA Inferred from Direct Assay more info	PubMed
involved_in myoblast fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor sem-2

NP_740846.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5204530..5208128 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170859.7 → NP_740846.1 Transcription factor sem-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740846.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8T3B9

Conserved Domains (1) summary

cd01388
Location:92 → 159

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...