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cln-3.2 Battenin [ Caenorhabditis elegans ]

Gene ID: 172171, updated on 4-Jan-2025

Summary

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Official Symbol
cln-3.2
Official Full Name
Battenin
Primary source
WormBase:WBGene00000540
Locus tag
CELE_C01G8.2
See related
AllianceGenome:WB:WBGene00000540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in determination of adult lifespan and regulation of egg-laying behavior. Predicted to be located in lysosomal membrane. Predicted to be active in lysosome. Is expressed in intestine and nervous system. Used to study neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Orthologous to human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cln-3.2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (5274693..5278708, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Retinol dehydrogenase 12-like Neighboring gene J domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deletion of the Caenorhabditis elegans homologues of the CLN3 gene, involved in human juvenile neuronal ceroid lipofuscinosis, causes a mild progeric phenotype. de Voer G, et al. J Inherit Metab Dis, 2005. PMID 16435200
  2. Genomic structure of three CLN3-like genes in Caenorhabditis elegans. Mitchell WA, et al. Eur J Paediatr Neurol, 2001. PMID 11588982
  3. Widespread organisation of C. elegans genes into operons: fact or function? Nimmo R, et al. Bioessays, 2002 Nov. PMID 12386927
  4. Caenorhabditis elegans homologues of the CLN3 gene, mutated in juvenile neuronal ceroid lipofuscinosis. De Voer G, et al. Eur J Paediatr Neurol, 2001. PMID 11588981
  5. A DNA nanodevice for mapping sodium at single-organelle resolution. Zou J, et al. Nat Biotechnol, 2024 Jul. PMID 37735265, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lysosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Battenin
NP_491556.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5274693..5278708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059155.9 → NP_491556.1  Battenin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491556.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECU8
    Conserved Domains (1) summary
    pfam02487
    Location:17 → 433
    CLN3; CLN3 protein
Nucleotide Protein
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