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rmh-1 RecQ-mediated genome instability protein 1 homolog [ Caenorhabditis elegans ]

Gene ID: 172212, updated on 4-Jan-2025

Summary

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Official Symbol
rmh-1
Official Full Name
RecQ-mediated genome instability protein 1 homolog
Primary source
WormBase:WBGene00019712
Locus tag
CELE_M01E11.3
See related
AllianceGenome:WB:WBGene00019712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA binding activity. Involved in several processes, including DNA recombination; positive regulation of brood size; and positive regulation of reciprocal meiotic recombination. Located in chromosome and nucleoplasm. Orthologous to human RMI1 (RecQ mediated genome instability 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See rmh-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (5573214..5576749)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DUF1080 domain-containing protein Neighboring gene CSD domain-containing protein Neighboring gene Kinesin motor domain-containing protein Neighboring gene Beta-catenin-like protein 1 N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex. Velkova M, et al. PLoS Genet, 2021 Jul. PMID 34252074, Free PMC Article
  2. C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata. Nguyen H, et al. PLoS Genet, 2018 Oct. PMID 30379819, Free PMC Article
  3. Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance. Jagut M, et al. PLoS Biol, 2016 Mar. PMID 27011106, Free PMC Article
  4. The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline. Dello Stritto MR, et al. Nucleic Acids Res, 2022 Jun 10. PMID 35639927, Free PMC Article
  5. DNA topoisomerase 3 is required for efficient germ cell quality control. Dello Stritto MR, et al. J Cell Biol, 2021 Jun 7. PMID 33798260, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline.
    Title: The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline.
  2. RMH-1 functions during meiosis to promote both crossover and non-crossover homologous recombination at appropriate chromosomal sites
    Title: Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in chiasma assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of brood size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RecQ family helicase-topoisomerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RecQ-mediated genome instability protein 1 homolog
NP_491632.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5573214..5576749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059231.9 → NP_491632.1  RecQ-mediated genome instability protein 1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491632.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91399
    Conserved Domains (1) summary
    pfam08585
    Location:13 → 223
    RMI1_N; RecQ mediated genome instability protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91399.1

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