lim-7 LIM/homeobox protein lim-7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lim-7
Official Full Name: LIM/homeobox protein lim-7
Primary source: WormBase:WBGene00002989
Locus tag: CELE_C04F1.3
See related: AllianceGenome:WB:WBGene00002989
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; head morphogenesis; and pharynx development. Located in nucleus. Is expressed in several structures, including body wall musculature; gonadal sheath cell; intestine; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1) and ISL2 (ISL LIM homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lim-7 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (5716574..5725809)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A lim-7 deletion allele causes early larval lethality with terminal phenotypes including uncoordination, detached pharynx, constipation and morphological defects.
Title: Characterization of the Caenorhabditis elegans Islet LIM-homeodomain ortholog, lim-7.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C04F1.3 (e-PCR)
- UniSTS:321906

STS1-128 (e-PCR)
- UniSTS:241613

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron fate specification	IEA Inferred from Electronic Annotation more info
involved_in pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LIM/homeobox protein lim-7

NP_491668.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5716574..5725809

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059267.4 → NP_491668.1 LIM/homeobox protein lim-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491668.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EC36

Conserved Domains (3) summary

cd09366
Location:56 → 110

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

smart00389
Location:267 → 321

HOX; Homeodomain

cl02475
Location:118 → 172

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers