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obr-4 Oxysterol-binding protein [ Caenorhabditis elegans ]

Gene ID: 172253, updated on 9-Dec-2024

Summary

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Official Symbol
obr-4
Official Full Name
Oxysterol-binding protein
Primary source
WormBase:WBGene00016331
Locus tag
CELE_C32F10.1
See related
AllianceGenome:WB:WBGene00016331
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calmodulin binding activity. Predicted to be involved in lipid transport. Predicted to be active in Golgi apparatus; cytosol; and membrane. Is expressed in nervous system; reproductive system; and tail. Orthologous to human OSBPL9 (oxysterol binding protein like 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See obr-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (5829391..5834637)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-2 Neighboring gene alanine transaminase Neighboring gene ncRNA Neighboring gene Potassium channel domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Homeobox domain-containing protein;Homeobox protein ceh-12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
  2. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Shen X, et al. Cell Calcium, 2008 May. PMID 17854888
  3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Oxysterol-binding protein
NP_001367357.1
  • Confirmed by transcript evidence
NP_491691.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5829391..5834637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059290.8 → NP_491691.1  Oxysterol-binding protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491691.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01686
    Conserved Domains (3) summary
    cd13290
    Location:1 → 100
    PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
    pfam00169
    Location:1 → 93
    PH; PH domain
    pfam01237
    Location:318 → 666
    Oxysterol_BP; Oxysterol-binding protein

  2. NM_001380388.1 → NP_001367357.1  Oxysterol-binding protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I7N6
    Conserved Domains (1) summary
    pfam01237
    Location:42 → 393
    Oxysterol_BP; Oxysterol-binding protein
Nucleotide Protein
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