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tyr-4 ShKT domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172263, updated on 2-Nov-2024

Summary

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Official Symbol
tyr-4
Official Full Name
ShKT domain-containing protein
Primary source
WormBase:WBGene00016419
Locus tag
CELE_C34G6.2
See related
AllianceGenome:WB:WBGene00016419
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity and oxidoreductase activity. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human DCT (dopachrome tautomerase); TYR (tyrosinase); and TYRP1 (tyrosinase related protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tyr-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (5898303..5902115)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene P-GlycoProtein related Neighboring gene Non-histone chromosomal protein HMG-14 Neighboring gene Signal transducing adapter molecule 1 Neighboring gene HEAT repeat protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New insights into the evolution of metazoan tyrosinase gene family. Esposito R, et al. PLoS One, 2012. PMID 22536431, Free PMC Article
  2. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
  3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ShKT domain-containing protein
NP_491709.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5898303..5902115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059308.9 → NP_491709.1  ShKT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491709.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01497
    Conserved Domains (3) summary
    smart00254
    Location:502 → 536
    ShKT; ShK toxin domain
    pfam00264
    Location:137 → 319
    Tyrosinase; Common central domain of tyrosinase
    pfam01549
    Location:611 → 645
    ShK; ShK domain-like
Nucleotide Protein
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