stam-1 Signal transducing adapter molecule 1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: stam-1
Official Full Name: Signal transducing adapter molecule 1
Primary source: WormBase:WBGene00004109
Locus tag: CELE_C34G6.7
See related: AllianceGenome:WB:WBGene00004109
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin binding activity. Involved in several processes, including ephrin receptor signaling pathway; protein localization to non-motile cilium; and response to hermaphrodite contact. Located in cilium and early endosome. Part of ESCRT-0 complex. Is expressed in male gonad; neurons; and pharyngeal-intestinal valve. Used to study polycystic kidney disease. Orthologous to several human genes including STAM (signal transducing adaptor molecule). [provided by Alliance of Genome Resources, Jan 2025]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See stam-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (5902105..5904695, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data reveal that the STAM-Hrs complex, which down-regulates ligand-activated growth factor receptors from the cell surface of yeast and mammalian cells, also regulates the localization and signaling of a ciliary PC1 receptor-TRPP2 complex.[STAM]
Title: STAM and Hrs down-regulate ciliary TRP receptors.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

C34G6.7 (e-PCR)
- UniSTS:308719

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ephrin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to non-motile cilium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hermaphrodite contact	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESCRT-0 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT-0 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Signal transducing adapter molecule 1

NP_491710.2

Confirmed by transcript evidence

NP_871813.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5902105..5904695 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059309.9 → NP_491710.2 Signal transducing adapter molecule 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491710.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O01498, Q8I7I2

Conserved Domains (2) summary

cd03568
Location:12 → 155

VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...

cl17036
Location:222 → 274

SH3; Src Homology 3 domain superfamily
NM_182013.8 → NP_871813.1 Signal transducing adapter molecule 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871813.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01498

Conserved Domains (2) summary

cd03568
Location:4 → 147

VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...

cl17036
Location:214 → 266

SH3; Src Homology 3 domain superfamily