haf-9 ABC-type antigen peptide transporter [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: haf-9
Official Full Name: ABC-type antigen peptide transporter
Primary source: WormBase:WBGene00001819
Locus tag: CELE_ZK484.2
See related: AllianceGenome:WB:WBGene00001819
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in lysosomal transport and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in lysosomal membrane. Is expressed in intestine and rectal gland cell. Orthologous to human ABCB9 (ATP binding cassette subfamily B member 9). [provided by Alliance of Genome Resources, Jan 2025]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See haf-9 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 16

Sequence:: Chromosome: I; NC_003279.8 (6081812..6085957)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HAF-4- and HAF-9-localizing organelles are distinct intestinal organelles associated with the endocytic pathway.
Title: Characterization of HAF-4- and HAF-9-localizing organelles as distinct organelles in Caenorhabditis elegans intestinal cells.
HAF-4 and HAF-9 form a heterodimer; knockdown experiments suggest that HAF-4-HAF-9 heterodimer formation is required for their stabilization.
Title: Co-operative function and mutual stabilization of the half ATP-binding cassette transporters HAF-4 and HAF-9 in Caenorhabditis elegans.
These results demonstrate that two ABC transporters, HAF-4 and HAF-9, are related to intestinal granular formation and some other physiological aspects.
Title: Normal formation of a subset of intestinal granules in Caenorhabditis elegans requires ATP-binding cassette transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAP-like.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

ZK484.2 (e-PCR)
- UniSTS:310497

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in lysosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide transport	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to chemical	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: ABC-type antigen peptide transporter

NP_491754.1

Confirmed by transcript evidence

NP_871810.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6081812..6085957

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059353.8 → NP_491754.1 ABC-type antigen peptide transporter [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491754.1

Status: REVIEWED

UniProtKB/TrEMBL

O44897

Conserved Domains (1) summary

TIGR00958
Location:19 → 757

3a01208; Conjugate Transporter-2 (CT2) Family protein
NM_182010.5 → NP_871810.1 ABC-type antigen peptide transporter [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871810.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IA64

Conserved Domains (1) summary

TIGR00958
Location:19 → 664

3a01208; Conjugate Transporter-2 (CT2) Family protein