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fars-1 phenylalanine--tRNA ligase [ Caenorhabditis elegans ]

Gene ID: 172311, updated on 4-Jan-2025

Summary

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Official Symbol
fars-1
Official Full Name
phenylalanine--tRNA ligase
Primary source
WormBase:WBGene00001497
Locus tag
CELE_T08B2.9
See related
AllianceGenome:WB:WBGene00001497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phenylalanine-tRNA ligase activity. Involved in translation. Predicted to be part of phenylalanine-tRNA ligase complex. Predicted to be active in cytoplasm. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See fars-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (6211983..6214586, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Enoyl-CoA hydratase Neighboring gene Large ribosomal subunit protein uL23m Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene RNA-binding protein 5 Neighboring gene Small ribosomal subunit protein eS17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling. Lee EC, et al. Am J Physiol Cell Physiol, 2012 Dec 15. PMID 23076791, Free PMC Article
  2. Alignment of the genetic and physical maps in the dpy-5 bli-4 (I) region of C. elegans by the serial cosmid rescue of lethal mutations. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230901
  3. Global Proteomic Response of Caenorhabditis elegans Against PemK(Sa) Toxin. Mir DA, et al. Front Cell Infect Microbiol, 2019. PMID 31214513, Free PMC Article
  4. Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230900
  5. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phenylalanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phenylalanine--tRNA ligase
NP_001379817.1
  • Confirmed by transcript evidence
NP_491792.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6211983..6214586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059391.6 → NP_491792.1  phenylalanine--tRNA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491792.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GYS8
    Conserved Domains (2) summary
    PTZ00326
    Location:65 → 539
    PTZ00326; phenylalanyl-tRNA synthetase alpha chain; Provisional
    cl02776
    Location:7 → 55
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. NM_001392410.1 → NP_001379817.1  phenylalanine--tRNA ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86B36
    Conserved Domains (1) summary
    PTZ00326
    Location:9 → 483
    PTZ00326; phenylalanyl-tRNA synthetase alpha chain; Provisional
Nucleotide Protein
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