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lpd-2 LiPid Depleted [ Caenorhabditis elegans ]

Gene ID: 172320, updated on 4-Jan-2025

Summary

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Official Symbol
lpd-2
Official Full Name
LiPid Depleted
Primary source
WormBase:WBGene00003059
Locus tag
CELE_C48E7.3
See related
AllianceGenome:WB:WBGene00003059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in filopodium. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in nervous system. Orthologous to human NGDN (neuroguidin). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lpd-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (6253701..6254947)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Olfactomedin-like domain-containing protein Neighboring gene CCAAT/enhancer-binding protein homolog 2 Neighboring gene DNA-directed RNA polymerase III subunit RPC3 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defective lipid metabolism associated with mutation in klf-2 and klf-3: important roles of essential dietary salts in fat storage. Ling J, et al. Nutr Metab (Lond), 2017. PMID 28261316, Free PMC Article
  2. C elegans: a model for exploring the genetics of fat storage. McKay RM, et al. Dev Cell, 2003 Jan. PMID 12530969, Free PMC Article
  3. IRE-1 and HSP-4 contribute to energy homeostasis via fasting-induced lipases in C. elegans. Jo H, et al. Cell Metab, 2009 May. PMID 19416714
  4. Transcription factors regulating the fate and developmental potential of a multipotent progenitor in Caenorhabditis elegans. Soukup EM, et al. G3 (Bethesda), 2022 Nov 4. PMID 36063055, Free PMC Article
  5. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LiPid Depleted
NP_491806.2
  • Product from WormBase gene class lpd;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6253701..6254947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059405.7 → NP_491806.2  LiPid Depleted [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491806.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IG68
    Conserved Domains (1) summary
    pfam04000
    Location:13 → 91
    Sas10_Utp3; Sas10/Utp3/C1D family
Nucleotide Protein
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