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mctp-1 C2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172382, updated on 2-Nov-2024

Summary

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Official Symbol
mctp-1
Official Full Name
C2 domain-containing protein
Primary source
WormBase:WBGene00017063
Locus tag
CELE_D2092.1
See related
AllianceGenome:WB:WBGene00017063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Predicted to be located in membrane. Predicted to be active in synaptic vesicle membrane. Is expressed in ciliated neurons; spermatheca; and ventral cord neurons. Orthologous to human MCTP1 (multiple C2 and transmembrane domain containing 1) and MCTP2 (multiple C2 and transmembrane domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mctp-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
17
Sequence:
Chromosome: I; NC_003279.8 (6629569..6637429, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein Phosphatase Four Regulatory subunit Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Peptidase S1 domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MCTP-1 modulates neurotransmitter release in C. elegans. Téllez-Arreola JL, et al. Mol Cell Neurosci, 2020 Sep. PMID 32650044
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C2 domain-containing protein
NP_001382264.1
  • Confirmed by transcript evidence
NP_001382265.1
  • Confirmed by transcript evidence
NP_001382287.1
  • Confirmed by transcript evidence
NP_001382288.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6629569..6637429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001395337.1 → NP_001382288.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E9P851
    Conserved Domains (3) summary
    cd04042
    Location:144 → 263
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:301 → 412
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:451 → 569
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

  2. NM_001395339.1 → NP_001382287.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZJ6
    Conserved Domains (3) summary
    cd04042
    Location:58 → 177
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:215 → 326
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:365 → 483
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

  3. NM_001395338.1 → NP_001382264.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D7ZEX2
    Conserved Domains (3) summary
    cd04042
    Location:104 → 223
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:261 → 372
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:411 → 529
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

  4. NM_001395340.1 → NP_001382265.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8D7ZET0
    Conserved Domains (2) summary
    cd08376
    Location:20 → 131
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:170 → 288
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
Nucleotide Protein
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