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pdi-3 Protein disulfide-isomerase [ Caenorhabditis elegans ]

Gene ID: 172433, updated on 9-Dec-2024

Summary

Official Symbol
pdi-3
Official Full Name
Protein disulfide-isomerase
Primary source
WormBase:WBGene00003964
Locus tag
CELE_H06O01.1
See related
AllianceGenome:WB:WBGene00003964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein disulfide isomerase activity and protein-glutamine gamma-glutamyltransferase activity. Involved in several processes, including collagen and cuticulin-based cuticle development; egg-laying behavior; and male anatomical structure morphogenesis. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See pdi-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (7015912..7020797, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein ctg-1 Neighboring gene DNA helicase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquilin

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein disulfide isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-glutamine gamma-glutamyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in body morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in collagen and cuticulin-based cuticle development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in collagen and cuticulin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in egg-laying behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nematode male tail mating organ morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nematode male tail tip morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell shape IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Protein disulfide-isomerase
NP_491995.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7015912..7020797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059594.9NP_491995.1  Protein disulfide-isomerase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491995.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED07
    Conserved Domains (5) summary
    cd02995
    Location:364465
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cd03069
    Location:130232
    PDI_b_ERp57; PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b; ERp57 (or ERp60) exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting ...
    cd03073
    Location:236344
    PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
    TIGR01130
    Location:21477
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    cl00388
    Location:26127
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold