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unc-14 RUN domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172450, updated on 4-Jan-2025

Summary

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Official Symbol
unc-14
Official Full Name
RUN domain-containing protein
Primary source
WormBase:WBGene00006753
Locus tag
CELE_K10D3.2
See related
AllianceGenome:WB:WBGene00006753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase binding activity and scaffold protein binding activity. Involved in regulation of protein localization and synaptic vesicle localization. Located in neuron projection. Is expressed in several structures, including hypodermis; intestine; motor neurons; muscle cell; and uterus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 61. Orthologous to human RUSC1 (RUN and SH3 domain containing 1) and RUSC2 (RUN and SH3 domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See unc-14 in Genome Data Viewer
Location:
chromosome: I
Exon count:
10
Sequence:
Chromosome: I; NC_003279.8 (7122614..7128246, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Glutamate receptor ionotropic, kainate glr-3 Neighboring gene Uncharacterized protein Neighboring gene TAFII28-like protein domain-containing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51. Ogura K, et al. Genes Dev, 1997 Jul 15. PMID 9242488
  2. Caenorhabditis elegans HIF-1 Is Broadly Required for Survival in Hydrogen Sulfide. Topalidou I, et al. G3 (Bethesda), 2017 Nov 6. PMID 28889102, Free PMC Article
  3. The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans. Lai T, et al. Development, 2004 Dec. PMID 15539493
  4. The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans. Ogura K, et al. Development, 2006 Sep. PMID 16887826
  5. Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans. Ogura K, et al. Development, 2010 May. PMID 20392746, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The autophagy-related kinase UNC-14 regulates the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans.
    Title: The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans.
  2. VAB-8 and UNC-14 are substrates that mediate the function of UNC-51 in axon outgrowth
    Title: The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.
  3. unc-14 binds to kinesin-1 and unc-16 complex and regulates synaptic vesicle localization.
    Title: The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RUN domain-containing protein
NP_492018.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7122614..7128246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059617.7 → NP_492018.1  RUN domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492018.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECQ1
    Conserved Domains (1) summary
    smart00593
    Location:471 → 535
    RUN; domain involved in Ras-like GTPase signaling
Nucleotide Protein
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