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lin-61 Protein lin-61 [ Caenorhabditis elegans ]

Gene ID: 172467, updated on 4-Jan-2025

Summary

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Official Symbol
lin-61
Official Full Name
Protein lin-61
Primary source
WormBase:WBGene00003041
Locus tag
CELE_R06C7.7
See related
AllianceGenome:WB:WBGene00003041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity and histone binding activity. Involved in vulval development. Located in chromatin and nucleus. Is expressed widely. Orthologous to several human genes including L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) and MBTD1 (mbt domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lin-61 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (7248827..7251282, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Chondroitin proteoglycan 3 Neighboring gene Protein N-terminal glutamine amidohydrolase Neighboring gene Adenylosuccinate lyase Neighboring gene Mitotic checkpoint serine/threonine-protein kinase bub-1 Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A role for the malignant brain tumour (MBT) domain protein LIN-61 in DNA double-strand break repair by homologous recombination. Johnson NM, et al. PLoS Genet, 2013. PMID 23505385, Free PMC Article
  2. SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity. Delaney CE, et al. Nat Struct Mol Biol, 2022 Feb. PMID 35102319, Free PMC Article
  3. A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress. McMurchy AN, et al. Elife, 2017 Mar 15. PMID 28294943, Free PMC Article
  4. A Forward Genetic Screen for Suppressors of Somatic P Granules in Caenorhabditis elegans. Kelly AL, et al. G3 (Bethesda), 2015 Jun 22. PMID 26100681, Free PMC Article
  5. Reevaluation of whether a soma-to-germ-line transformation extends lifespan in Caenorhabditis elegans. Knutson AK, et al. Proc Natl Acad Sci U S A, 2016 Mar 29. PMID 26976573, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression.
    Title: Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression.
  2. Using a novel reporter system that monitors repair of a defined DSB in C. elegans somatic cells, we show that LIN-61 contributes to homologous recombination .
    Title: A role for the malignant brain tumour (MBT) domain protein LIN-61 in DNA double-strand break repair by homologous recombination.
  3. H3K9me2/3 interaction of LIN-61 is required for C. elegans vulva development within the synMuvB pathway
    Title: H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development.
  4. These data indicate that while the class B synMuv genes act together to regulate vulval development, lin-61 functions separately from some class B synMuv proteins in other biological processes.
    Title: LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein lin-61
NP_001122501.1
  • Confirmed by transcript evidence
NP_492050.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7248827..7251282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059649.6 → NP_492050.3  Protein lin-61 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492050.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B2D6M2
    Conserved Domains (2) summary
    smart00561
    Location:390 → 486
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam02820
    Location:312 → 384
    MBT; mbt repeat

  2. NM_001129029.3 → NP_001122501.1  Protein lin-61 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122501.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B2D6M2, Q21769
    Conserved Domains (2) summary
    smart00561
    Location:511 → 607
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam02820
    Location:433 → 505
    MBT; mbt repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2D6M2.1

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