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T23G11.7 HAUS6_N domain-containing protein;Vacuolar protein sorting-associated protein VTA1 homolog [ Caenorhabditis elegans ]

Gene ID: 172528, updated on 2-Nov-2024

Summary

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Official Symbol
T23G11.7
Official Full Name
HAUS6_N domain-containing protein;Vacuolar protein sorting-associated protein VTA1 homolog
Primary source
WormBase:WBGene00011972
Locus tag
CELE_T23G11.7
See related
AllianceGenome:WB:WBGene00011972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable SNARE binding activity. Predicted to be involved in SNARE complex assembly. Predicted to be located in endosome membrane. Predicted to be active in endosome and lytic vacuole. Orthologous to human UVRAG (UV radiation resistance associated). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T23G11.7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (7679448..7683045)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Golgin-84 Neighboring gene Rho-GAP domain-containing protein Neighboring gene eLRR (extracellular Leucine-Rich Repeat) ONly Neighboring gene Hepatocellular carcinoma-associated antigen 59

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegans. Harper NC, et al. Dev Cell, 2011 Nov 15. PMID 22018922, Free PMC Article
  2. A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode. Tsushima H, et al. PLoS One, 2013. PMID 23424658, Free PMC Article
  3. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
  4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lytic vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
HAUS6_N domain-containing protein;Vacuolar protein sorting-associated protein VTA1 homolog
NP_001379199.1
  • Confirmed by transcript evidence
NP_492139.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7679448..7683045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392592.1 → NP_001379199.1  HAUS6_N domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    P90969

  2. NM_059738.8 → NP_492139.3  Vacuolar protein sorting-associated protein VTA1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492139.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45812
    Conserved Domains (1) summary
    pfam04652
    Location:17 → 147
    Vta1; Vta1 like
Nucleotide Protein
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