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gna-2 Glucosamine 6-phosphate N-acetyltransferase [ Caenorhabditis elegans ]

Gene ID: 172533, updated on 4-Jan-2025

Summary

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Official Symbol
gna-2
Official Full Name
Glucosamine 6-phosphate N-acetyltransferase
Primary source
WormBase:WBGene00001647
Locus tag
CELE_T23G11.2
See related
AllianceGenome:WB:WBGene00001647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glucosamine 6-phosphate N-acetyltransferase activity. Involved in chitin biosynthetic process and eggshell formation. Predicted to be located in Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and late endosome. Is expressed in pharynx. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See gna-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (7699682..7700958)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Female germline-specific tumor suppressor gld-1 Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene Transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response. Horn M, et al. iScience, 2020 Mar 27. PMID 32086012, Free PMC Article
  2. Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans. Lee MH, et al. Genes Dev, 2004 May 1. PMID 15105376, Free PMC Article
  3. Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1. Ruegenberg S, et al. Nat Commun, 2021 Apr 12. PMID 33846315, Free PMC Article
  4. Disruption of O-GlcNAc Cycling in C. elegans Perturbs Nucleotide Sugar Pools and Complex Glycans. Ghosh SK, et al. Front Endocrinol (Lausanne), 2014. PMID 25505447, Free PMC Article
  5. Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Schumacher B, et al. Cell, 2005 Feb 11. PMID 15707894

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables glucosamine 6-phosphate N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosamine 6-phosphate N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eggshell formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Glucosamine 6-phosphate N-acetyltransferase
NP_492144.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7699682..7700958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059743.8 → NP_492144.1  Glucosamine 6-phosphate N-acetyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492144.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EC27
    Conserved Domains (1) summary
    cl17182
    Location:198 → 338
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Nucleotide Protein
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